Antioxidant action and potential antidiabetic properties of an isoflavonoid-containing soyabean phytochemical extract (SPE)

Krishnaveni Vedavanam, Sairavee Srijayanta, James O'Reilly, Amala Soumyanath, Helen Wiseman

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

The potential role of oestrogenic agents, antioxidants and intestinal glucose-uptake inhibitors in the treatment of diabetes is briefly reviewed. Reports in the literature suggest that oestrogen replacement therapy may favourably modulate glucose homeostasis. A soya phytochemical extract (SPE) containing the isoflavone phytoestrogens genistein and daidzein (mostly in their glycone forms as genistin and daidzin) was investigated as an antioxidant and modulator of intestinal glucose-transport. In the present study, SPE was found to protect against glucose-induced oxidation of human low density lipoproteins (LDL) in vitro. Equol (a gut bacterial metabolite of daidzein) was a more effective antioxidant than daidzein or genistein in this system and was of similar antioxidant potency to the dietary flavonols quercetin and kaempferol and to the endogenous antioxidant 17β-oestradiol. SPE was found to be an inhibitor of glucose uptake into rabbit intestinal brush border membrane vesicles in vitro, though of weaker potency than the classical sodium dependent glucose transporter (SGLT) inhibitor, phlorizin. Thus SPE displays a range of properties which may be of benefit in diabetes, namely as an oestrogenic agent, an inhibitor of intestinal glucose-uptake and a preventive agent for glucose-induced lipid peroxidation.

Original languageEnglish (US)
Pages (from-to)601-608
Number of pages8
JournalPhytotherapy Research
Volume13
Issue number7
DOIs
StatePublished - Nov 1999
Externally publishedYes

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Phytochemicals
Hypoglycemic Agents
Action Potentials
Antioxidants
Glucose
Genistein
Medical problems
Sodium-Glucose Transport Proteins
Equol
Phlorhizin
Phytoestrogens
Flavonols
Estrogen Replacement Therapy
Isoflavones
Facilitative Glucose Transport Proteins
Quercetin
Brushes
Microvilli
Metabolites
LDL Lipoproteins

Keywords

  • Antidiabetic
  • Antioxidant
  • Brush border membrane vesicles
  • Glucose transport
  • Liposomal lipid peroxidation
  • Soyabean phytochemical extract

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Antioxidant action and potential antidiabetic properties of an isoflavonoid-containing soyabean phytochemical extract (SPE). / Vedavanam, Krishnaveni; Srijayanta, Sairavee; O'Reilly, James; Soumyanath, Amala; Wiseman, Helen.

In: Phytotherapy Research, Vol. 13, No. 7, 11.1999, p. 601-608.

Research output: Contribution to journalArticle

Vedavanam, Krishnaveni ; Srijayanta, Sairavee ; O'Reilly, James ; Soumyanath, Amala ; Wiseman, Helen. / Antioxidant action and potential antidiabetic properties of an isoflavonoid-containing soyabean phytochemical extract (SPE). In: Phytotherapy Research. 1999 ; Vol. 13, No. 7. pp. 601-608.
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