Antinociceptive properties of intrathecal dexmedetomidine in rats

Brock Fisher, Mark H. Zornow, Tony L. Yaksh, Bradley M. Peterson

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

Dexmedetomidine is a highly selective α2-adrenoceptor agonist. In this study, the intrathecal administration of dexmedetomidine into the rat lumbar subarachnoid space produced dose-dependent, prolonged antinociception as measured by hot plate and tail flick testing. Intrathecal administration of 3 or 10 μg of dexmedetomidine increased hot plate and tail flick latencies to cutoff values within 15 min of injection. Animals receiving 1 μg of intrathecal dexmedetomidine did not show any significant antinociception when compared to saline controls. The intrathecal administration of the α2-adrenoceptor antagonist, idazoxan, ablated all measurable antinociception produced by the prior injection of 10 μg of dexmedetomidine.

Original languageEnglish (US)
Pages (from-to)221-225
Number of pages5
JournalEuropean Journal of Pharmacology
Volume192
Issue number2
DOIs
StatePublished - Jan 10 1991

Keywords

  • (Intrathecal)
  • Antinociception
  • Dexmedetomidine
  • α-Adrenoceptors

ASJC Scopus subject areas

  • Pharmacology

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