Antinociception mediated by the periaqueductal gray is attenuated by orphanin FQ

Michael M. Morgan; Judith E. Grisel; Carolyn S. Robbins; David K. Grandy

doi:10.1097/00001756-199711100-00003

Antinociception mediated by the periaqueductal gray is attenuated by orphanin FQ

Michael M. Morgan, Judith E. Grisel, Carolyn S. Robbins, David K. Grandy

Research output: Contribution to journal › Article › peer-review

101 Scopus citations

Abstract

Orphanin FQ or nociceptin (OFQ/N_1-17) is a recently discovered peptide which, upon intracerebroventricular administration, reverses opioid- mediated analgesias. OFQ/N_1-17 terminals are located in the periaqueductal gray (PAG), a structure known to be involved in pain modulation, suggesting that the functional anti-opioid effects of OFQ/N_1- ₁₇ are mediated by PAG neurons. To test this, subsequent microinjections of morphine or kainic acid and OFQ/N_1-17 were made into the PAG of awake rats. Administration of OFQ/N_1-17 attenuated the tail flick inhibition produced by both morphine and kainic acid microinjection. OFQ/N_1-17 attenuation of antinociception produced by a neuroexcitant indicates that OFQ/N_1-17 reverses opioid antinociception by inhibiting PAG output neurons.

Original language	English (US)
Pages (from-to)	3431-3434
Number of pages	4
Journal	NeuroReport
Volume	8
Issue number	16
DOIs	https://doi.org/10.1097/00001756-199711100-00003
State	Published - Jan 1 1997

Keywords

Analgesia
Anti-opioid peptide
Morphine
Nociceptin
Opioid
Pain modulation

ASJC Scopus subject areas

Neuroscience(all)

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10.1097/00001756-199711100-00003

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title = "Antinociception mediated by the periaqueductal gray is attenuated by orphanin FQ",

abstract = "Orphanin FQ or nociceptin (OFQ/N1-17) is a recently discovered peptide which, upon intracerebroventricular administration, reverses opioid- mediated analgesias. OFQ/N1-17 terminals are located in the periaqueductal gray (PAG), a structure known to be involved in pain modulation, suggesting that the functional anti-opioid effects of OFQ/N1- 17 are mediated by PAG neurons. To test this, subsequent microinjections of morphine or kainic acid and OFQ/N1-17 were made into the PAG of awake rats. Administration of OFQ/N1-17 attenuated the tail flick inhibition produced by both morphine and kainic acid microinjection. OFQ/N1-17 attenuation of antinociception produced by a neuroexcitant indicates that OFQ/N1-17 reverses opioid antinociception by inhibiting PAG output neurons.",

keywords = "Analgesia, Anti-opioid peptide, Morphine, Nociceptin, Opioid, Pain modulation",

author = "Morgan, {Michael M.} and Grisel, {Judith E.} and Robbins, {Carolyn S.} and Grandy, {David K.}",

year = "1997",

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doi = "10.1097/00001756-199711100-00003",

language = "English (US)",

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T1 - Antinociception mediated by the periaqueductal gray is attenuated by orphanin FQ

AU - Morgan, Michael M.

AU - Grisel, Judith E.

AU - Robbins, Carolyn S.

AU - Grandy, David K.

PY - 1997/1/1

Y1 - 1997/1/1

N2 - Orphanin FQ or nociceptin (OFQ/N1-17) is a recently discovered peptide which, upon intracerebroventricular administration, reverses opioid- mediated analgesias. OFQ/N1-17 terminals are located in the periaqueductal gray (PAG), a structure known to be involved in pain modulation, suggesting that the functional anti-opioid effects of OFQ/N1- 17 are mediated by PAG neurons. To test this, subsequent microinjections of morphine or kainic acid and OFQ/N1-17 were made into the PAG of awake rats. Administration of OFQ/N1-17 attenuated the tail flick inhibition produced by both morphine and kainic acid microinjection. OFQ/N1-17 attenuation of antinociception produced by a neuroexcitant indicates that OFQ/N1-17 reverses opioid antinociception by inhibiting PAG output neurons.

AB - Orphanin FQ or nociceptin (OFQ/N1-17) is a recently discovered peptide which, upon intracerebroventricular administration, reverses opioid- mediated analgesias. OFQ/N1-17 terminals are located in the periaqueductal gray (PAG), a structure known to be involved in pain modulation, suggesting that the functional anti-opioid effects of OFQ/N1- 17 are mediated by PAG neurons. To test this, subsequent microinjections of morphine or kainic acid and OFQ/N1-17 were made into the PAG of awake rats. Administration of OFQ/N1-17 attenuated the tail flick inhibition produced by both morphine and kainic acid microinjection. OFQ/N1-17 attenuation of antinociception produced by a neuroexcitant indicates that OFQ/N1-17 reverses opioid antinociception by inhibiting PAG output neurons.

KW - Analgesia

KW - Anti-opioid peptide

KW - Morphine

KW - Nociceptin

KW - Opioid

KW - Pain modulation

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JO - NeuroReport

JF - NeuroReport

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ER -

Antinociception mediated by the periaqueductal gray is attenuated by orphanin FQ

Abstract

Keywords

ASJC Scopus subject areas

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