Antinociception mediated by the periaqueductal gray is attenuated by orphanin FQ

Michael M. Morgan, Judith E. Grisel, Carolyn S. Robbins, David Grandy

    Research output: Contribution to journalArticle

    94 Citations (Scopus)

    Abstract

    Orphanin FQ or nociceptin (OFQ/N 1-17) is a recently discovered peptide which, upon intracerebroventricular administration, reverses opioid- mediated analgesias. OFQ/N 1-17 terminals are located in the periaqueductal gray (PAG), a structure known to be involved in pain modulation, suggesting that the functional anti-opioid effects of OFQ/N 1- 17 are mediated by PAG neurons. To test this, subsequent microinjections of morphine or kainic acid and OFQ/N 1-17 were made into the PAG of awake rats. Administration of OFQ/N 1-17 attenuated the tail flick inhibition produced by both morphine and kainic acid microinjection. OFQ/N 1-17 attenuation of antinociception produced by a neuroexcitant indicates that OFQ/N 1-17 reverses opioid antinociception by inhibiting PAG output neurons.

    Original languageEnglish (US)
    Pages (from-to)3431-3434
    Number of pages4
    JournalNeuroReport
    Volume8
    Issue number16
    StatePublished - 1997

    Fingerprint

    Periaqueductal Gray
    Opioid Analgesics
    Kainic Acid
    Microinjections
    Morphine
    Neurons
    Analgesia
    Tail
    Pain
    Peptides
    nociceptin

    Keywords

    • Analgesia
    • Anti-opioid peptide
    • Morphine
    • Nociceptin
    • Opioid
    • Pain modulation

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Morgan, M. M., Grisel, J. E., Robbins, C. S., & Grandy, D. (1997). Antinociception mediated by the periaqueductal gray is attenuated by orphanin FQ. NeuroReport, 8(16), 3431-3434.

    Antinociception mediated by the periaqueductal gray is attenuated by orphanin FQ. / Morgan, Michael M.; Grisel, Judith E.; Robbins, Carolyn S.; Grandy, David.

    In: NeuroReport, Vol. 8, No. 16, 1997, p. 3431-3434.

    Research output: Contribution to journalArticle

    Morgan, MM, Grisel, JE, Robbins, CS & Grandy, D 1997, 'Antinociception mediated by the periaqueductal gray is attenuated by orphanin FQ', NeuroReport, vol. 8, no. 16, pp. 3431-3434.
    Morgan MM, Grisel JE, Robbins CS, Grandy D. Antinociception mediated by the periaqueductal gray is attenuated by orphanin FQ. NeuroReport. 1997;8(16):3431-3434.
    Morgan, Michael M. ; Grisel, Judith E. ; Robbins, Carolyn S. ; Grandy, David. / Antinociception mediated by the periaqueductal gray is attenuated by orphanin FQ. In: NeuroReport. 1997 ; Vol. 8, No. 16. pp. 3431-3434.
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    N2 - Orphanin FQ or nociceptin (OFQ/N 1-17) is a recently discovered peptide which, upon intracerebroventricular administration, reverses opioid- mediated analgesias. OFQ/N 1-17 terminals are located in the periaqueductal gray (PAG), a structure known to be involved in pain modulation, suggesting that the functional anti-opioid effects of OFQ/N 1- 17 are mediated by PAG neurons. To test this, subsequent microinjections of morphine or kainic acid and OFQ/N 1-17 were made into the PAG of awake rats. Administration of OFQ/N 1-17 attenuated the tail flick inhibition produced by both morphine and kainic acid microinjection. OFQ/N 1-17 attenuation of antinociception produced by a neuroexcitant indicates that OFQ/N 1-17 reverses opioid antinociception by inhibiting PAG output neurons.

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