Abstract
Primary biliary cirrhosis (PBC) is a chronic, progressive autoimmune liver disease, which is characterized by nonsuppurative destruction of intrahepatic ducts, resulting in cholestasis, cirrhosis, and end-stage liver disease. Antimitochondrial antibodies (AMAs) are considered to be a highly sensitive and specific serological marker of PBC; however, a subset of patients who have biochemical and histopathological features consistent with PBC do not have detectable AMAs in their serum. This phenomenon is referred to as AMA-negative PBC. This article briefly reviews the literature on AMA-negative PBC and discusses the diagnosis and treatment of this condition in older adults.
Original language | English (US) |
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Pages (from-to) | 41-43 |
Number of pages | 3 |
Journal | Clinical Geriatrics |
Volume | 20 |
Issue number | 6 |
State | Published - Jun 2012 |
Externally published | Yes |
ASJC Scopus subject areas
- Geriatrics and Gerontology