Antihypertensive therapy in experimental diabetes

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Systemic hypertension is an important risk factor for the progression of diabetic glomerular disease. Recognition of this detrimental aspect has prompted intensive investigation into the mechanisms by which systemic hypertension promotes diabetic glomerulopathy, as well as into potential benefits of antihypertensive therapy. Studies in diabetic rats, both normotensive and hypertensive, have established that certain antihypertensive regimens effectively slow the development of albuminuria and glomerular sclerosis. Most consistently effective have been angiotensin-converting enzyme inhibitors, which may act to protect the kidney by several different mechanisms. Other antihypertensive regimens have been less consistent.

Original languageEnglish (US)
JournalJournal of the American Society of Nephrology
Volume3
Issue number4 SUPPL.
StatePublished - Oct 1992

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Investigational Therapies
Antihypertensive Agents
Hypertension
Albuminuria
Sclerosis
Angiotensin-Converting Enzyme Inhibitors
Kidney
Therapeutics

Keywords

  • Albuminuria
  • Angiotensin
  • Diabetes
  • Hypertension

ASJC Scopus subject areas

  • Nephrology

Cite this

Antihypertensive therapy in experimental diabetes. / Anderson, Sharon.

In: Journal of the American Society of Nephrology, Vol. 3, No. 4 SUPPL., 10.1992.

Research output: Contribution to journalArticle

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