Antigens for CD4 and CD8 T cells in tuberculosis

Cecilia S. Lindestam Arlehamn, David Lewinsohn, Alessandro Sette, Deborah Lewinsohn

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Abstract

Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis (MTB), represents an important cause of morbidity and mortality worldwide for which an improved vaccine and immunodiagnostics are urgently needed. CD4+ and CD8+ T cells play an important role in host defense to TB. Definition of the antigens recognized by these T cells is critical for improved understanding of the immunobiology of TB and for development of vaccines and diagnostics. Herein, the antigens and epitopes recognized by classically HLA class I- and II — restricted CD4+ and CD8+ T cells in humans infected with MTB are reviewed. Immunodominant antigens and epitopes have been defined using approaches targeting particular TB proteins or classes of proteins and by genome-wide discovery approaches. Antigens and epitopes recognized by classically restricted CD4+ and CD8+ T cells show extensive breadth and diversity in MTB-infected humans.

Original languageEnglish (US)
JournalCold Spring Harbor Perspectives in Medicine
Volume4
Issue number7
DOIs
StatePublished - Jan 1 2014

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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