Antigens for CD4 and CD8 T cells in tuberculosis

Cecilia S. Lindestam Arlehamn, David Lewinsohn, Alessandro Sette, Deborah Lewinsohn

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis (MTB), represents an important cause of morbidity and mortality worldwide for which an improved vaccine and immunodiagnostics are urgently needed. CD4+ and CD8+ T cells play an important role in host defense to TB. Definition of the antigens recognized by these T cells is critical for improved understanding of the immunobiology of TB and for development of vaccines and diagnostics. Herein, the antigens and epitopes recognized by classically HLA class I- and II — restricted CD4+ and CD8+ T cells in humans infected with MTB are reviewed. Immunodominant antigens and epitopes have been defined using approaches targeting particular TB proteins or classes of proteins and by genome-wide discovery approaches. Antigens and epitopes recognized by classically restricted CD4+ and CD8+ T cells show extensive breadth and diversity in MTB-infected humans.

Original languageEnglish (US)
JournalCold Spring Harbor perspectives in medicine
Volume4
Issue number7
DOIs
StatePublished - 2014

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CD8 Antigens
CD4 Antigens
T-cells
Tuberculosis
Mycobacterium tuberculosis
T-Lymphocytes
Immunodominant Epitopes
Antigens
Epitopes
Vaccines
Tuberculosis Vaccines
Proteins
Genes
Genome
Morbidity
Mortality
Infection

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Antigens for CD4 and CD8 T cells in tuberculosis. / Lindestam Arlehamn, Cecilia S.; Lewinsohn, David; Sette, Alessandro; Lewinsohn, Deborah.

In: Cold Spring Harbor perspectives in medicine, Vol. 4, No. 7, 2014.

Research output: Contribution to journalArticle

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