TY - JOUR
T1 - Antigens for CD4 and CD8 T cells in tuberculosis
AU - Lindestam Arlehamn, Cecilia S.
AU - Lewinsohn, David
AU - Sette, Alessandro
AU - Lewinsohn, Deborah
N1 - Publisher Copyright:
©2014 Cold Spring Harbor Laboratory Press; all rights reserved.
PY - 2014
Y1 - 2014
N2 - Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis (MTB), represents an important cause of morbidity and mortality worldwide for which an improved vaccine and immunodiagnostics are urgently needed. CD4+ and CD8+ T cells play an important role in host defense to TB. Definition of the antigens recognized by these T cells is critical for improved understanding of the immunobiology of TB and for development of vaccines and diagnostics. Herein, the antigens and epitopes recognized by classically HLA class I- and II — restricted CD4+ and CD8+ T cells in humans infected with MTB are reviewed. Immunodominant antigens and epitopes have been defined using approaches targeting particular TB proteins or classes of proteins and by genome-wide discovery approaches. Antigens and epitopes recognized by classically restricted CD4+ and CD8+ T cells show extensive breadth and diversity in MTB-infected humans.
AB - Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis (MTB), represents an important cause of morbidity and mortality worldwide for which an improved vaccine and immunodiagnostics are urgently needed. CD4+ and CD8+ T cells play an important role in host defense to TB. Definition of the antigens recognized by these T cells is critical for improved understanding of the immunobiology of TB and for development of vaccines and diagnostics. Herein, the antigens and epitopes recognized by classically HLA class I- and II — restricted CD4+ and CD8+ T cells in humans infected with MTB are reviewed. Immunodominant antigens and epitopes have been defined using approaches targeting particular TB proteins or classes of proteins and by genome-wide discovery approaches. Antigens and epitopes recognized by classically restricted CD4+ and CD8+ T cells show extensive breadth and diversity in MTB-infected humans.
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U2 - 10.1101/cshperspect.a018465
DO - 10.1101/cshperspect.a018465
M3 - Article
C2 - 24852051
AN - SCOPUS:84907581808
SN - 2157-1422
VL - 4
JO - Cold Spring Harbor Perspectives in Medicine
JF - Cold Spring Harbor Perspectives in Medicine
IS - 7
ER -