Antigen presentation by MHC class I and its regulation by interferon γ

Klaus Früh, Young Yang

Research output: Contribution to journalArticlepeer-review

224 Scopus citations


Antigen processing by MHC class I molecules begins with the generation of peptides by proteolytic breakdown of proteins. IFN-γ upregulates gene expression of several proteasomal subunits as well as the proteasome regulator PA28; this implicated their role in antigen degradation. Crystallographic, mutational and biochemical studies contributed to our understanding of the basic principles of proteasomal protein degradation and the consequences of IFN-γ induction for proteasome function. In addition, nonproteasomal mechanisms seem to be involved in antigen degradation. Leucine aminopeptidase, which is also upregulated by IFN-γ, was shown to collaborate with the proteasome for epitope production and unknown proteases seem to compensate for the loss of proteasomal degradation in the presence of proteasome inhibitors. Thus, a rather complex picture emerges for the rules governing peptide production in the presence or absence of IFN-γ.

Original languageEnglish (US)
Pages (from-to)76-81
Number of pages6
JournalCurrent opinion in immunology
Issue number1
StatePublished - Feb 1 1999
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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