Anticoagulants

Jeffrey D. Crawford, Bruce A. Warden, Timothy Liem

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    Care of the vascular surgical patient requires an updated, evidence-based approach to the management of anticoagulation. In addition to managing arterial and venous thrombi, vascular surgeons also must be adept at managing the frequently encountered co-morbid conditions of our patient population as well as careful perioperative and intraoperative decisions to balance the risk of bleeding and recurrent thrombosis. e homeostatic mechanisms governing this delicate and complex process are regulated by the endothelium, extracellular tissue and circulating blood proteins and cells. An in-depth review of the nuances and complex interactions of the coagulation cascade is beyond the scope of this chapter. is chapter reviews current FDA-approved anticoagulants, focusing on mechanisms of action and pharmacokinetics, indications and supporting data, important side eects, drug monitoring and reversal and perioperative management in an attempt to improve the care of the vascular patient. e recent introduction of several new anticoagulants and reversal agents makes this topic especially pertinent (Figure 8.1).

    Original languageEnglish (US)
    Title of host publicationVascular Surgery
    Subtitle of host publicationPrinciples and Practice, Fourth Edition
    PublisherCRC Press
    Pages101-122
    Number of pages22
    ISBN (Electronic)9781482239461
    ISBN (Print)9781498780469
    DOIs
    StatePublished - Jan 1 2017

    Fingerprint

    Anticoagulants
    Blood Vessels
    Thrombosis
    Drug Monitoring
    Endothelium
    Blood Proteins
    Blood Cells
    Patient Care
    Pharmacokinetics
    Hemorrhage
    Population
    icodextrin
    Surgeons

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    Crawford, J. D., Warden, B. A., & Liem, T. (2017). Anticoagulants. In Vascular Surgery: Principles and Practice, Fourth Edition (pp. 101-122). CRC Press. https://doi.org/10.1201/9781315381770

    Anticoagulants. / Crawford, Jeffrey D.; Warden, Bruce A.; Liem, Timothy.

    Vascular Surgery: Principles and Practice, Fourth Edition. CRC Press, 2017. p. 101-122.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Crawford, JD, Warden, BA & Liem, T 2017, Anticoagulants. in Vascular Surgery: Principles and Practice, Fourth Edition. CRC Press, pp. 101-122. https://doi.org/10.1201/9781315381770
    Crawford JD, Warden BA, Liem T. Anticoagulants. In Vascular Surgery: Principles and Practice, Fourth Edition. CRC Press. 2017. p. 101-122 https://doi.org/10.1201/9781315381770
    Crawford, Jeffrey D. ; Warden, Bruce A. ; Liem, Timothy. / Anticoagulants. Vascular Surgery: Principles and Practice, Fourth Edition. CRC Press, 2017. pp. 101-122
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