Anticipatory postural adjustments prior to step initiation are hypometric in untreated Parkinson's disease: An accelerometer-based approach

M. Mancini, C. Zampieri, P. Carlson-Kuhta, L. Chiari, F. B. Horak

Research output: Contribution to journalArticle

79 Scopus citations

Abstract

Background and purpose: Anticipatory postural adjustments (APAs), prior to step initiation, are bradykinetic in advanced Parkinson's disease (PD) and may be one of the factors associated with 'start hesitation'. However, little is known about APAs in the early stage of PD. In this study, we determined whether body-worn accelerometers could be used to characterize step initiation deficits in subjects with early-to-moderate, untreated PD. Methods: Eleven PD and 12 healthy control subjects were asked to take two steps. Postural adjustments were compared from center of pressure (COP) and from acceleration of the trunk at the center of mass level (L5). Results: Our findings show that APAs measured from the peak COP displacement toward the swing leg and the peak trunk acceleration toward the stance leg were smaller in untreated PD compared with control subjects. The magnitude of APAs measured from peak COP displacements and accelerations were correlated. Conclusion: These results suggest that quantitative analysis of step initiation from one accelerometer on the trunk could provide useful information for the characterization of patients in early stages of PD, when clinical evidence of start hesitation may not be detectable. Ambulatory monitoring of step initiation is also promising for monitoring patient progression in the home environment, and eventually providing feedback for preventing freezing of gait episodes.

Original languageEnglish (US)
Pages (from-to)1028-1034
Number of pages7
JournalEuropean Journal of Neurology
Volume16
Issue number9
DOIs
StatePublished - Sep 1 2009

Keywords

  • Accelerometers
  • Freezing
  • Parkinson's disease
  • Posture
  • Step initiation

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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