Antibodies induced by a primary cytomegalovirus infection react with human herpesvirus 6 proteins

Stuart P. Adler, Michael McVoy, Sunwen Chou, Sue Hempfling, Koichi Yamanishi, William Britt

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

After a primary human cytomegalovirus (HCMV) infection, antibody titer to human herpes-virus 6 (HHV-6) rises. To determine if this occurs because of simultaneous infection with both viruses, serologic responses to these viruses were investigated among healthy women who received a live HCMV vaccine or acquired HCMV from an infected child. Both vaccination and natural infection caused four-fold or greater titer rises to HHV-6. Analysis of sera from 5 children with primary HHV-6 showed no serologic response to HCMV. Absorption of 7 sera with HCMV antigens reduced titers to HHV-6 by two- to fourfold. Immunoblot analysis of sera obtained from 10 persons before and after a primary HCMV infection revealed that after HCMV infection, 2 persons developed IgG reactivity to the 116-kDa protein (gp116) of HHV-6 and to two cleavage products of this protein. Reactivity to HHV-6 gp116 appeared after HCMV seroconversion and was removed by absorption of sera with HCMV glycoprotein gB (gB), indicating that antibodies to HCMV gB cross-react with HHV-6 gp116, the likely gB homologue of HHV-6. The serologic diagnosis of HHV-6 infection requires excluding a primary HCMV infection.

Original languageEnglish (US)
Pages (from-to)1119-1126
Number of pages8
JournalJournal of Infectious Diseases
Volume168
Issue number5
StatePublished - Nov 1993
Externally publishedYes

Fingerprint

Human Herpesvirus 6
Cytomegalovirus Infections
Antibodies
Proteins
Viruses
Cytomegalovirus
Serum
Cytomegalovirus Vaccines

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Adler, S. P., McVoy, M., Chou, S., Hempfling, S., Yamanishi, K., & Britt, W. (1993). Antibodies induced by a primary cytomegalovirus infection react with human herpesvirus 6 proteins. Journal of Infectious Diseases, 168(5), 1119-1126.

Antibodies induced by a primary cytomegalovirus infection react with human herpesvirus 6 proteins. / Adler, Stuart P.; McVoy, Michael; Chou, Sunwen; Hempfling, Sue; Yamanishi, Koichi; Britt, William.

In: Journal of Infectious Diseases, Vol. 168, No. 5, 11.1993, p. 1119-1126.

Research output: Contribution to journalArticle

Adler, SP, McVoy, M, Chou, S, Hempfling, S, Yamanishi, K & Britt, W 1993, 'Antibodies induced by a primary cytomegalovirus infection react with human herpesvirus 6 proteins', Journal of Infectious Diseases, vol. 168, no. 5, pp. 1119-1126.
Adler, Stuart P. ; McVoy, Michael ; Chou, Sunwen ; Hempfling, Sue ; Yamanishi, Koichi ; Britt, William. / Antibodies induced by a primary cytomegalovirus infection react with human herpesvirus 6 proteins. In: Journal of Infectious Diseases. 1993 ; Vol. 168, No. 5. pp. 1119-1126.
@article{db6962f83e4a4476bdd900284358790a,
title = "Antibodies induced by a primary cytomegalovirus infection react with human herpesvirus 6 proteins",
abstract = "After a primary human cytomegalovirus (HCMV) infection, antibody titer to human herpes-virus 6 (HHV-6) rises. To determine if this occurs because of simultaneous infection with both viruses, serologic responses to these viruses were investigated among healthy women who received a live HCMV vaccine or acquired HCMV from an infected child. Both vaccination and natural infection caused four-fold or greater titer rises to HHV-6. Analysis of sera from 5 children with primary HHV-6 showed no serologic response to HCMV. Absorption of 7 sera with HCMV antigens reduced titers to HHV-6 by two- to fourfold. Immunoblot analysis of sera obtained from 10 persons before and after a primary HCMV infection revealed that after HCMV infection, 2 persons developed IgG reactivity to the 116-kDa protein (gp116) of HHV-6 and to two cleavage products of this protein. Reactivity to HHV-6 gp116 appeared after HCMV seroconversion and was removed by absorption of sera with HCMV glycoprotein gB (gB), indicating that antibodies to HCMV gB cross-react with HHV-6 gp116, the likely gB homologue of HHV-6. The serologic diagnosis of HHV-6 infection requires excluding a primary HCMV infection.",
author = "Adler, {Stuart P.} and Michael McVoy and Sunwen Chou and Sue Hempfling and Koichi Yamanishi and William Britt",
year = "1993",
month = "11",
language = "English (US)",
volume = "168",
pages = "1119--1126",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "5",

}

TY - JOUR

T1 - Antibodies induced by a primary cytomegalovirus infection react with human herpesvirus 6 proteins

AU - Adler, Stuart P.

AU - McVoy, Michael

AU - Chou, Sunwen

AU - Hempfling, Sue

AU - Yamanishi, Koichi

AU - Britt, William

PY - 1993/11

Y1 - 1993/11

N2 - After a primary human cytomegalovirus (HCMV) infection, antibody titer to human herpes-virus 6 (HHV-6) rises. To determine if this occurs because of simultaneous infection with both viruses, serologic responses to these viruses were investigated among healthy women who received a live HCMV vaccine or acquired HCMV from an infected child. Both vaccination and natural infection caused four-fold or greater titer rises to HHV-6. Analysis of sera from 5 children with primary HHV-6 showed no serologic response to HCMV. Absorption of 7 sera with HCMV antigens reduced titers to HHV-6 by two- to fourfold. Immunoblot analysis of sera obtained from 10 persons before and after a primary HCMV infection revealed that after HCMV infection, 2 persons developed IgG reactivity to the 116-kDa protein (gp116) of HHV-6 and to two cleavage products of this protein. Reactivity to HHV-6 gp116 appeared after HCMV seroconversion and was removed by absorption of sera with HCMV glycoprotein gB (gB), indicating that antibodies to HCMV gB cross-react with HHV-6 gp116, the likely gB homologue of HHV-6. The serologic diagnosis of HHV-6 infection requires excluding a primary HCMV infection.

AB - After a primary human cytomegalovirus (HCMV) infection, antibody titer to human herpes-virus 6 (HHV-6) rises. To determine if this occurs because of simultaneous infection with both viruses, serologic responses to these viruses were investigated among healthy women who received a live HCMV vaccine or acquired HCMV from an infected child. Both vaccination and natural infection caused four-fold or greater titer rises to HHV-6. Analysis of sera from 5 children with primary HHV-6 showed no serologic response to HCMV. Absorption of 7 sera with HCMV antigens reduced titers to HHV-6 by two- to fourfold. Immunoblot analysis of sera obtained from 10 persons before and after a primary HCMV infection revealed that after HCMV infection, 2 persons developed IgG reactivity to the 116-kDa protein (gp116) of HHV-6 and to two cleavage products of this protein. Reactivity to HHV-6 gp116 appeared after HCMV seroconversion and was removed by absorption of sera with HCMV glycoprotein gB (gB), indicating that antibodies to HCMV gB cross-react with HHV-6 gp116, the likely gB homologue of HHV-6. The serologic diagnosis of HHV-6 infection requires excluding a primary HCMV infection.

UR - http://www.scopus.com/inward/record.url?scp=0027449378&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027449378&partnerID=8YFLogxK

M3 - Article

C2 - 8228344

AN - SCOPUS:0027449378

VL - 168

SP - 1119

EP - 1126

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 5

ER -