Antibodies against desmoglein 1 in healthy subjects in endemic and nonendemic areas of pemphigus foliaceus (fogo selvagem) in Peru

Alex Ortega Loayza, Willy Ramos, George Elgart, Peter Bouman, Gerardo Jiménez, Jack Avila, Isabel Rojas, María Vilcarromero, Jorge Hurtado, Gisella Lindo, Carlos Galarza

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Endemic pemphigus foliaceus or fogo selvagem is an autoimmune skin disease characterized by the presence of subcorneal superficial blisters and antibodies of the immunoglobulin G4 (IgG4) class specific for the desmosomal glycoprotein, desmoglein 1. In Peru, no studies have been published on the seroprevalence of antibodies against desmoglein 1 in healthy subjects from endemic foci. Subjects and methods: This was a cross-sectional study. The sample included 82 healthy subjects, 41 from the Pueblo Libre community, a focus of endemic pemphigus foliaceus, and 41 from a nonendemic urban area in Pucallpa City. Enzyme-linked immunosorbent assay (ELISA) was used to determine the presence of antibodies against desmoglein 1. Samples were processed and tested at the Department of Dermatology and Cutaneous Surgery, School of Medicine, University of Miami, Miami, Florida. Results: It was found that 31.7% of healthy individuals (13 subjects) from the endemic focus had anti-desmoglein 1 antibodies. A statistically significant association was found between the distance from the endemic focus and the presence of antibodies against desmoglein 1 in subjects living within the endemic focus Mantel-Haenszel odds ratio (OR), 3.34; P = 0.03; 95% confidence interval (CI), 1.06-10.48]. Agriculture as an occupation showed a statistically significant association with the presence of antibodies against desmoglein 1 (Mantel-Haenszel OR, 7.84; P <0.001; 95% CI, 2.47-24.87). Conclusions: Antibodies against desmoglein 1 are present in healthy subjects exposed to an endemic focus of pemphigus foliaceus (fogo selvagem). Agriculture is associated with a high risk of development of antibodies against desmoglein 1 in the endemic focus of the Pueblo Libre community.

Original languageEnglish (US)
Pages (from-to)538-542
Number of pages5
JournalInternational Journal of Dermatology
Volume45
Issue number5
DOIs
StatePublished - May 1 2006
Externally publishedYes

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Desmoglein 1
Peru
Pemphigus
Healthy Volunteers
Antibodies
Agriculture
Odds Ratio
Confidence Intervals
Dermatologic Surgical Procedures
Pemphigus and fogo selvagem
Immunoglobulin Isotypes
Seroepidemiologic Studies
Blister
Dermatology
Occupations
Skin Diseases
Autoimmune Diseases
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Medicine

ASJC Scopus subject areas

  • Dermatology

Cite this

Antibodies against desmoglein 1 in healthy subjects in endemic and nonendemic areas of pemphigus foliaceus (fogo selvagem) in Peru. / Ortega Loayza, Alex; Ramos, Willy; Elgart, George; Bouman, Peter; Jiménez, Gerardo; Avila, Jack; Rojas, Isabel; Vilcarromero, María; Hurtado, Jorge; Lindo, Gisella; Galarza, Carlos.

In: International Journal of Dermatology, Vol. 45, No. 5, 01.05.2006, p. 538-542.

Research output: Contribution to journalArticle

Ortega Loayza, A, Ramos, W, Elgart, G, Bouman, P, Jiménez, G, Avila, J, Rojas, I, Vilcarromero, M, Hurtado, J, Lindo, G & Galarza, C 2006, 'Antibodies against desmoglein 1 in healthy subjects in endemic and nonendemic areas of pemphigus foliaceus (fogo selvagem) in Peru', International Journal of Dermatology, vol. 45, no. 5, pp. 538-542. https://doi.org/10.1111/j.1365-4632.2006.02823.x
Ortega Loayza, Alex ; Ramos, Willy ; Elgart, George ; Bouman, Peter ; Jiménez, Gerardo ; Avila, Jack ; Rojas, Isabel ; Vilcarromero, María ; Hurtado, Jorge ; Lindo, Gisella ; Galarza, Carlos. / Antibodies against desmoglein 1 in healthy subjects in endemic and nonendemic areas of pemphigus foliaceus (fogo selvagem) in Peru. In: International Journal of Dermatology. 2006 ; Vol. 45, No. 5. pp. 538-542.
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abstract = "Background: Endemic pemphigus foliaceus or fogo selvagem is an autoimmune skin disease characterized by the presence of subcorneal superficial blisters and antibodies of the immunoglobulin G4 (IgG4) class specific for the desmosomal glycoprotein, desmoglein 1. In Peru, no studies have been published on the seroprevalence of antibodies against desmoglein 1 in healthy subjects from endemic foci. Subjects and methods: This was a cross-sectional study. The sample included 82 healthy subjects, 41 from the Pueblo Libre community, a focus of endemic pemphigus foliaceus, and 41 from a nonendemic urban area in Pucallpa City. Enzyme-linked immunosorbent assay (ELISA) was used to determine the presence of antibodies against desmoglein 1. Samples were processed and tested at the Department of Dermatology and Cutaneous Surgery, School of Medicine, University of Miami, Miami, Florida. Results: It was found that 31.7{\%} of healthy individuals (13 subjects) from the endemic focus had anti-desmoglein 1 antibodies. A statistically significant association was found between the distance from the endemic focus and the presence of antibodies against desmoglein 1 in subjects living within the endemic focus Mantel-Haenszel odds ratio (OR), 3.34; P = 0.03; 95{\%} confidence interval (CI), 1.06-10.48]. Agriculture as an occupation showed a statistically significant association with the presence of antibodies against desmoglein 1 (Mantel-Haenszel OR, 7.84; P <0.001; 95{\%} CI, 2.47-24.87). Conclusions: Antibodies against desmoglein 1 are present in healthy subjects exposed to an endemic focus of pemphigus foliaceus (fogo selvagem). Agriculture is associated with a high risk of development of antibodies against desmoglein 1 in the endemic focus of the Pueblo Libre community.",
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T1 - Antibodies against desmoglein 1 in healthy subjects in endemic and nonendemic areas of pemphigus foliaceus (fogo selvagem) in Peru

AU - Ortega Loayza, Alex

AU - Ramos, Willy

AU - Elgart, George

AU - Bouman, Peter

AU - Jiménez, Gerardo

AU - Avila, Jack

AU - Rojas, Isabel

AU - Vilcarromero, María

AU - Hurtado, Jorge

AU - Lindo, Gisella

AU - Galarza, Carlos

PY - 2006/5/1

Y1 - 2006/5/1

N2 - Background: Endemic pemphigus foliaceus or fogo selvagem is an autoimmune skin disease characterized by the presence of subcorneal superficial blisters and antibodies of the immunoglobulin G4 (IgG4) class specific for the desmosomal glycoprotein, desmoglein 1. In Peru, no studies have been published on the seroprevalence of antibodies against desmoglein 1 in healthy subjects from endemic foci. Subjects and methods: This was a cross-sectional study. The sample included 82 healthy subjects, 41 from the Pueblo Libre community, a focus of endemic pemphigus foliaceus, and 41 from a nonendemic urban area in Pucallpa City. Enzyme-linked immunosorbent assay (ELISA) was used to determine the presence of antibodies against desmoglein 1. Samples were processed and tested at the Department of Dermatology and Cutaneous Surgery, School of Medicine, University of Miami, Miami, Florida. Results: It was found that 31.7% of healthy individuals (13 subjects) from the endemic focus had anti-desmoglein 1 antibodies. A statistically significant association was found between the distance from the endemic focus and the presence of antibodies against desmoglein 1 in subjects living within the endemic focus Mantel-Haenszel odds ratio (OR), 3.34; P = 0.03; 95% confidence interval (CI), 1.06-10.48]. Agriculture as an occupation showed a statistically significant association with the presence of antibodies against desmoglein 1 (Mantel-Haenszel OR, 7.84; P <0.001; 95% CI, 2.47-24.87). Conclusions: Antibodies against desmoglein 1 are present in healthy subjects exposed to an endemic focus of pemphigus foliaceus (fogo selvagem). Agriculture is associated with a high risk of development of antibodies against desmoglein 1 in the endemic focus of the Pueblo Libre community.

AB - Background: Endemic pemphigus foliaceus or fogo selvagem is an autoimmune skin disease characterized by the presence of subcorneal superficial blisters and antibodies of the immunoglobulin G4 (IgG4) class specific for the desmosomal glycoprotein, desmoglein 1. In Peru, no studies have been published on the seroprevalence of antibodies against desmoglein 1 in healthy subjects from endemic foci. Subjects and methods: This was a cross-sectional study. The sample included 82 healthy subjects, 41 from the Pueblo Libre community, a focus of endemic pemphigus foliaceus, and 41 from a nonendemic urban area in Pucallpa City. Enzyme-linked immunosorbent assay (ELISA) was used to determine the presence of antibodies against desmoglein 1. Samples were processed and tested at the Department of Dermatology and Cutaneous Surgery, School of Medicine, University of Miami, Miami, Florida. Results: It was found that 31.7% of healthy individuals (13 subjects) from the endemic focus had anti-desmoglein 1 antibodies. A statistically significant association was found between the distance from the endemic focus and the presence of antibodies against desmoglein 1 in subjects living within the endemic focus Mantel-Haenszel odds ratio (OR), 3.34; P = 0.03; 95% confidence interval (CI), 1.06-10.48]. Agriculture as an occupation showed a statistically significant association with the presence of antibodies against desmoglein 1 (Mantel-Haenszel OR, 7.84; P <0.001; 95% CI, 2.47-24.87). Conclusions: Antibodies against desmoglein 1 are present in healthy subjects exposed to an endemic focus of pemphigus foliaceus (fogo selvagem). Agriculture is associated with a high risk of development of antibodies against desmoglein 1 in the endemic focus of the Pueblo Libre community.

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