Antiangiogenic agents in vitreoretinal disease

Christina Flaxel, H. Klassen, Z. J. Gregor

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Intraocular neovascularization is a serious complication in many common ischemic retinal disorders including diabetic retinopathy and retinal vein occlusion. Laser photocoagulation is the only treatment modality proven to alter the course of these disease processes. It has long been postulated that the ischemic retina promotes the expression of factors that lead to retinal neovascularization. The process of angiogenesis has been well described and is reviewed in detail with a discussion of specific molecules and growth factors acting at each stage. It is believed that vascular endothelial cells are maintained under normal conditions by homeostatic mechanisms in which normal suppressor factors actively prevent proliferation. These and other potential antiangiogenic agents are discussed in detail.

Original languageEnglish (US)
Pages (from-to)421-433
Number of pages13
JournalOphthalmology Clinics of North America
Volume10
Issue number3
StatePublished - 1997
Externally publishedYes

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Retinal Neovascularization
Retinal Vein Occlusion
Angiogenesis Inhibitors
Light Coagulation
Diabetic Retinopathy
Retina
Intercellular Signaling Peptides and Proteins
Lasers
Endothelial Cells
Therapeutics

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Antiangiogenic agents in vitreoretinal disease. / Flaxel, Christina; Klassen, H.; Gregor, Z. J.

In: Ophthalmology Clinics of North America, Vol. 10, No. 3, 1997, p. 421-433.

Research output: Contribution to journalArticle

Flaxel, C, Klassen, H & Gregor, ZJ 1997, 'Antiangiogenic agents in vitreoretinal disease', Ophthalmology Clinics of North America, vol. 10, no. 3, pp. 421-433.
Flaxel, Christina ; Klassen, H. ; Gregor, Z. J. / Antiangiogenic agents in vitreoretinal disease. In: Ophthalmology Clinics of North America. 1997 ; Vol. 10, No. 3. pp. 421-433.
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