Intraocular neovascularization is a serious complication in many common ischemic retinal disorders including diabetic retinopathy and retinal vein occlusion. Laser photocoagulation is the only treatment modality proven to alter the course of these disease processes. It has long been postulated that the ischemic retina promotes the expression of factors that lead to retinal neovascularization. The process of angiogenesis has been well described and is reviewed in detail with a discussion of specific molecules and growth factors acting at each stage. It is believed that vascular endothelial cells are maintained under normal conditions by homeostatic mechanisms in which normal suppressor factors actively prevent proliferation. These and other potential antiangiogenic agents are discussed in detail.
|Original language||English (US)|
|Number of pages||13|
|Journal||Ophthalmology Clinics of North America|
|State||Published - Oct 29 1997|
ASJC Scopus subject areas