Antiangiogenic agents in vitreoretinal disease

C. J. Flaxel, H. Klassen, Z. J. Gregor

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Intraocular neovascularization is a serious complication in many common ischemic retinal disorders including diabetic retinopathy and retinal vein occlusion. Laser photocoagulation is the only treatment modality proven to alter the course of these disease processes. It has long been postulated that the ischemic retina promotes the expression of factors that lead to retinal neovascularization. The process of angiogenesis has been well described and is reviewed in detail with a discussion of specific molecules and growth factors acting at each stage. It is believed that vascular endothelial cells are maintained under normal conditions by homeostatic mechanisms in which normal suppressor factors actively prevent proliferation. These and other potential antiangiogenic agents are discussed in detail.

Original languageEnglish (US)
Pages (from-to)421-433
Number of pages13
JournalOphthalmology Clinics of North America
Issue number3
StatePublished - Oct 29 1997
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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