Anti-SS-A antibodies and fetal outcome in maternal systemic lupus erythematosus

R. Ramsey-Goldman, D. Hom, J. S. Deng, G. C. Ziegler, Leslie Kahl, V. D. Steen, R. E. LaPorte, T. A. Medsger

Research output: Contribution to journalArticle

138 Citations (Scopus)

Abstract

In 155 women with systemic lupus erythematosus, there were no significant differences in the rates of fertility or adverse fetal outcome between the 47 (30%) with serum anti-SS-A antibody and the 108 without anti-SS-A, except in the frequency of congenital heart block. This complication occurred in 6 of 96 pregnancies in women with anti-SS-A and was associated with high-titer maternal antibody. The overall risk of a woman with lupus having an infant with congenital heart block was estimated to be 1:60, but the risk was considerably higher (1:20) if anti-SS-A antibody was present.

Original languageEnglish (US)
Pages (from-to)1269-1273
Number of pages5
JournalArthritis and Rheumatism
Volume29
Issue number10
StatePublished - 1986
Externally publishedYes

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Systemic Lupus Erythematosus
Mothers
Birth Rate
Pregnancy
Antibodies
Serum
SS-A antibodies
Congenital heart block

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Ramsey-Goldman, R., Hom, D., Deng, J. S., Ziegler, G. C., Kahl, L., Steen, V. D., ... Medsger, T. A. (1986). Anti-SS-A antibodies and fetal outcome in maternal systemic lupus erythematosus. Arthritis and Rheumatism, 29(10), 1269-1273.

Anti-SS-A antibodies and fetal outcome in maternal systemic lupus erythematosus. / Ramsey-Goldman, R.; Hom, D.; Deng, J. S.; Ziegler, G. C.; Kahl, Leslie; Steen, V. D.; LaPorte, R. E.; Medsger, T. A.

In: Arthritis and Rheumatism, Vol. 29, No. 10, 1986, p. 1269-1273.

Research output: Contribution to journalArticle

Ramsey-Goldman, R, Hom, D, Deng, JS, Ziegler, GC, Kahl, L, Steen, VD, LaPorte, RE & Medsger, TA 1986, 'Anti-SS-A antibodies and fetal outcome in maternal systemic lupus erythematosus', Arthritis and Rheumatism, vol. 29, no. 10, pp. 1269-1273.
Ramsey-Goldman R, Hom D, Deng JS, Ziegler GC, Kahl L, Steen VD et al. Anti-SS-A antibodies and fetal outcome in maternal systemic lupus erythematosus. Arthritis and Rheumatism. 1986;29(10):1269-1273.
Ramsey-Goldman, R. ; Hom, D. ; Deng, J. S. ; Ziegler, G. C. ; Kahl, Leslie ; Steen, V. D. ; LaPorte, R. E. ; Medsger, T. A. / Anti-SS-A antibodies and fetal outcome in maternal systemic lupus erythematosus. In: Arthritis and Rheumatism. 1986 ; Vol. 29, No. 10. pp. 1269-1273.
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