Anti-proliferative effects of progesterone antagonists in the primate endometrium: A potential role for the androgen receptor

Robert M. Brenner, Ov D. Slayden, Hilary O.D. Critchley

    Research output: Contribution to journalReview article

    52 Scopus citations

    Abstract

    In women and non-human primates, treatment with anti-progestins suppresses oestrogen-dependent mitotic activity in the endometrial glands. This anti-proliferative effect is paradoxical, because anti-progestins do not bind to the oestrogen receptor. Although this phenomenon has been termed a 'non-competitive anti-oestrogenic effect', it does not occur in all species or in other regions of the primate reproductive tract, so is best referred to as an 'endometrial anti-proliferative effect'. The abundance of androgen receptors is greatly increased by anti-progestin treatment, especially in the glandular epithelium in non-human primates and women. Such an increase could lead to an enhancement of androgen action in the endometrium. As androgens suppress oestrogen-dependent endometrial proliferation, the increased abundance of androgen receptors could mediate the anti-proliferative effects of anti-progestin treatment. This brief review evaluates the implications of these findings.

    Original languageEnglish (US)
    Pages (from-to)167-172
    Number of pages6
    JournalReproduction
    Volume124
    Issue number2
    DOIs
    StatePublished - Jan 1 2002

    ASJC Scopus subject areas

    • Reproductive Medicine
    • Embryology
    • Endocrinology
    • Obstetrics and Gynecology
    • Cell Biology

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