Anti-Müllerian hormone: Biology, role in ovarian function and clinical significance

David Seifer, Reshef Tal

Research output: Book/ReportBook

Abstract

This is the first book published that discusses state of the art research regarding AMH in human reproduction and medicine. This unique and vital protein impacts a variety of fundamental processes within the ovaries and testes. Since its discovery in 1947, every medical student has learned about the role AMH plays in embryonic sexual differentiation. However, the last fifteen years have witnessed AMH emerge from the bench to the bedside, from a scientific curiosity to a useful diagnostic tool with clinical utility and therapeutic applications. In female reproduction, AMH has undergone a virtual renaissance after it was discovered in the human ovarian follicle and later to reflect ovarian reserve. Since that time, much has been learned regarding the role of AMH in female reproductive aging and a number of other gynecological conditions. This is reflected by a number of peer-reviewed publications on AMH in human adult females, which has increased exponentially over the past three decades. It is only in the last decade that AMH has become an important marker of ovarian response, guiding clinical decision making in assisted reproductive technology (ART) as well as a useful aid in the diagnosis of polycystic ovarian syndrome (PCOS). In male reproduction, AMH has become a diagnostic tool in the complex evaluation of infants with intersex conditions, including ambiguous genitalia and cryptorchidism. The chapters of this book bring together experienced investigators with a variety of research interests in different aspects of AMH. Each contributor has conducted clinical, translational and/or basic research in the field of AMH. Each has an appreciation of what is known and an aspiration for solving what remains to be discovered. A better understanding of AMH pathophysiology may lead to the development of pharmacological treatments using AMH agonists and/or antagonists for a host of reproductive challenges. These include: the possible retardation of ovarian aging and menopause; a chemoprotectant for fertility preservation prior to chemotherapy; a tool to better control ovarian response to ART and/or to mitigate the deleterious effects of polycystic ovary syndrome; and a treatment for endometriosis, adenomyosis and/or endometrial and ovarian cancers. This book enables the reader to review the past, understand the present and consider the future of this multifaceted protein in the fields of reproductive medicine and gynecology.

Original languageEnglish (US)
PublisherNova Science Publishers, Inc.
Number of pages339
ISBN (Electronic)9781634840170
ISBN (Print)9781634840125
StatePublished - Jan 1 2016
Externally publishedYes

Fingerprint

Reproduction
Disorders of Sex Development
Assisted Reproductive Techniques
Polycystic Ovary Syndrome
Hormones
Research
Fertility Preservation
Adenomyosis
Reproductive Medicine
Sex Differentiation
Exploratory Behavior
Cryptorchidism
Ovarian Follicle
Endometriosis
Endometrial Neoplasms
Menopause
Gynecology
Medical Students
Ovarian Neoplasms
Publications

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Seifer, D., & Tal, R. (2016). Anti-Müllerian hormone: Biology, role in ovarian function and clinical significance. Nova Science Publishers, Inc.

Anti-Müllerian hormone : Biology, role in ovarian function and clinical significance. / Seifer, David; Tal, Reshef.

Nova Science Publishers, Inc., 2016. 339 p.

Research output: Book/ReportBook

Seifer, D & Tal, R 2016, Anti-Müllerian hormone: Biology, role in ovarian function and clinical significance. Nova Science Publishers, Inc.
Seifer D, Tal R. Anti-Müllerian hormone: Biology, role in ovarian function and clinical significance. Nova Science Publishers, Inc., 2016. 339 p.
Seifer, David ; Tal, Reshef. / Anti-Müllerian hormone : Biology, role in ovarian function and clinical significance. Nova Science Publishers, Inc., 2016. 339 p.
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