Anti-LRP2 nephropathy with concurrent kidney infiltration by lymphoma

Ashley Gamayo, Douglas Hecox, Lance Dicker, Lisa Vecchiarelli, Philipp W. Raess, Mazdak Khalighi, Nicole K. Andeen

Research output: Contribution to journalArticlepeer-review

Abstract

Anti-low-density lipoprotein receptor-related lipoprotein 2 (LRP2) nephropathy/anti-brush border antibody disease is rare and characterized by tubular basement membrane, Bowman's capsule and glomerular subepithelial immune deposits on kidney biopsy. No reported cases have occurred in patients with lymphoproliferative disorders or monoclonal gammopathies. We present two cases of anti-LRP2 nephropathy that occurred in patients with progressive low-grade B-cell lymphoma and had concurrent kidney infiltration by lymphoma on biopsy. We speculate that underlying immune dysregulation related to lymphoma may contribute to the development of this rare autoimmune kidney disease in some patients.

Original languageEnglish (US)
Pages (from-to)468-472
Number of pages5
JournalClinical Kidney Journal
Volume13
Issue number3
DOIs
StatePublished - Jun 1 2020

Keywords

  • anti-brush border antibody
  • anti-LRP2 nephropathy
  • chronic lymphocytic leukemia
  • kidney biopsy
  • LDL receptor-related protein 2
  • lymphoplasmacytic lymphoma
  • megalin
  • renal pathology
  • Waldenstrom macroglobulinemia

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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