Anti-LRP2 nephropathy with concurrent kidney infiltration by lymphoma

Ashley Gamayo; Douglas Hecox; Lance Dicker; Lisa Vecchiarelli; Philipp W. Raess; Mazdak Khalighi; Nicole K. Andeen

doi:10.1093/ckj/sfz166

Anti-LRP2 nephropathy with concurrent kidney infiltration by lymphoma

Ashley Gamayo, Douglas Hecox, Lance Dicker, Lisa Vecchiarelli, Philipp W. Raess, Mazdak Khalighi, Nicole K. Andeen

Pathology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Anti-low-density lipoprotein receptor-related lipoprotein 2 (LRP2) nephropathy/anti-brush border antibody disease is rare and characterized by tubular basement membrane, Bowman's capsule and glomerular subepithelial immune deposits on kidney biopsy. No reported cases have occurred in patients with lymphoproliferative disorders or monoclonal gammopathies. We present two cases of anti-LRP2 nephropathy that occurred in patients with progressive low-grade B-cell lymphoma and had concurrent kidney infiltration by lymphoma on biopsy. We speculate that underlying immune dysregulation related to lymphoma may contribute to the development of this rare autoimmune kidney disease in some patients.

Original language	English (US)
Pages (from-to)	468-472
Number of pages	5
Journal	Clinical Kidney Journal
Volume	13
Issue number	3
DOIs	https://doi.org/10.1093/ckj/sfz166
State	Published - Jun 1 2020

Keywords

LDL receptor-related protein 2
Waldenstrom macroglobulinemia
anti-LRP2 nephropathy
anti-brush border antibody
chronic lymphocytic leukemia
kidney biopsy
lymphoplasmacytic lymphoma
megalin
renal pathology

ASJC Scopus subject areas

Nephrology
Transplantation

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10.1093/ckj/sfz166

Cite this

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title = "Anti-LRP2 nephropathy with concurrent kidney infiltration by lymphoma",

abstract = "Anti-low-density lipoprotein receptor-related lipoprotein 2 (LRP2) nephropathy/anti-brush border antibody disease is rare and characterized by tubular basement membrane, Bowman's capsule and glomerular subepithelial immune deposits on kidney biopsy. No reported cases have occurred in patients with lymphoproliferative disorders or monoclonal gammopathies. We present two cases of anti-LRP2 nephropathy that occurred in patients with progressive low-grade B-cell lymphoma and had concurrent kidney infiltration by lymphoma on biopsy. We speculate that underlying immune dysregulation related to lymphoma may contribute to the development of this rare autoimmune kidney disease in some patients.",

keywords = "LDL receptor-related protein 2, Waldenstrom macroglobulinemia, anti-LRP2 nephropathy, anti-brush border antibody, chronic lymphocytic leukemia, kidney biopsy, lymphoplasmacytic lymphoma, megalin, renal pathology",

author = "Ashley Gamayo and Douglas Hecox and Lance Dicker and Lisa Vecchiarelli and Raess, {Philipp W.} and Mazdak Khalighi and Andeen, {Nicole K.}",

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AU - Gamayo, Ashley

AU - Hecox, Douglas

AU - Dicker, Lance

AU - Vecchiarelli, Lisa

AU - Raess, Philipp W.

AU - Khalighi, Mazdak

AU - Andeen, Nicole K.

PY - 2020/6/1

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AB - Anti-low-density lipoprotein receptor-related lipoprotein 2 (LRP2) nephropathy/anti-brush border antibody disease is rare and characterized by tubular basement membrane, Bowman's capsule and glomerular subepithelial immune deposits on kidney biopsy. No reported cases have occurred in patients with lymphoproliferative disorders or monoclonal gammopathies. We present two cases of anti-LRP2 nephropathy that occurred in patients with progressive low-grade B-cell lymphoma and had concurrent kidney infiltration by lymphoma on biopsy. We speculate that underlying immune dysregulation related to lymphoma may contribute to the development of this rare autoimmune kidney disease in some patients.

KW - LDL receptor-related protein 2

KW - Waldenstrom macroglobulinemia

KW - anti-LRP2 nephropathy

KW - anti-brush border antibody

KW - chronic lymphocytic leukemia

KW - kidney biopsy

KW - lymphoplasmacytic lymphoma

KW - megalin

KW - renal pathology

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Anti-LRP2 nephropathy with concurrent kidney infiltration by lymphoma

Abstract

Keywords

ASJC Scopus subject areas

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