It is becoming increasingly apparent that nuclear antigens can be expressed on the surfaces of certain cells. The authors provide evidence that anti-DNA antibodies are reactive with DNA on the surface of monocytes and B lymphocytes. The DNA isolated from monocytes sedimented in a 17.8S position, corresponding to a molecular weight of 4.6 x 106; it was mainly double-stranded with many short single stranded regions. In one patient with active systemic lupus erythematosus experiments indicated that anti-DNA antibodies had interacted in vivo with the cell surface DNA on monocytes. The functional significance, if any, of these findings remains to be determined.
|Original language||English (US)|
|Number of pages||7|
|Journal||Journal of Rheumatology|
|State||Published - Dec 1 1986|
ASJC Scopus subject areas
- Immunology and Allergy