Anti-DNA antibodies react with DNA expressed on the surface of monocytes and B lymphocytes

R. M. Bennett, J. Davis, M. Merritt

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

It is becoming increasingly apparent that nuclear antigens can be expressed on the surfaces of certain cells. The authors provide evidence that anti-DNA antibodies are reactive with DNA on the surface of monocytes and B lymphocytes. The DNA isolated from monocytes sedimented in a 17.8S position, corresponding to a molecular weight of 4.6 x 106; it was mainly double-stranded with many short single stranded regions. In one patient with active systemic lupus erythematosus experiments indicated that anti-DNA antibodies had interacted in vivo with the cell surface DNA on monocytes. The functional significance, if any, of these findings remains to be determined.

Original languageEnglish (US)
Pages (from-to)679-685
Number of pages7
JournalJournal of Rheumatology
Volume13
Issue number4
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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