Anti-DNA antibodies react with DNA expressed on the surface of monocytes and B lymphocytes

R. M. Bennett, J. Davis, M. Merritt

    Research output: Contribution to journalArticle

    21 Scopus citations

    Abstract

    It is becoming increasingly apparent that nuclear antigens can be expressed on the surfaces of certain cells. The authors provide evidence that anti-DNA antibodies are reactive with DNA on the surface of monocytes and B lymphocytes. The DNA isolated from monocytes sedimented in a 17.8S position, corresponding to a molecular weight of 4.6 x 106; it was mainly double-stranded with many short single stranded regions. In one patient with active systemic lupus erythematosus experiments indicated that anti-DNA antibodies had interacted in vivo with the cell surface DNA on monocytes. The functional significance, if any, of these findings remains to be determined.

    Original languageEnglish (US)
    Pages (from-to)679-685
    Number of pages7
    JournalJournal of Rheumatology
    Volume13
    Issue number4
    StatePublished - Dec 1 1986

    ASJC Scopus subject areas

    • Rheumatology
    • Immunology and Allergy
    • Immunology

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