Anti-DNA antibodies react with DNA expressed on the surface of monocytes and B lymphocytes

Robert (Rob) Bennett, J. Davis, M. Merritt

    Research output: Contribution to journalArticle

    21 Citations (Scopus)

    Abstract

    It is becoming increasingly apparent that nuclear antigens can be expressed on the surfaces of certain cells. The authors provide evidence that anti-DNA antibodies are reactive with DNA on the surface of monocytes and B lymphocytes. The DNA isolated from monocytes sedimented in a 17.8S position, corresponding to a molecular weight of 4.6 x 106; it was mainly double-stranded with many short single stranded regions. In one patient with active systemic lupus erythematosus experiments indicated that anti-DNA antibodies had interacted in vivo with the cell surface DNA on monocytes. The functional significance, if any, of these findings remains to be determined.

    Original languageEnglish (US)
    Pages (from-to)679-685
    Number of pages7
    JournalJournal of Rheumatology
    Volume13
    Issue number4
    StatePublished - 1986

    Fingerprint

    Antinuclear Antibodies
    Monocytes
    B-Lymphocytes
    DNA
    Nuclear Antigens
    Systemic Lupus Erythematosus
    Molecular Weight

    ASJC Scopus subject areas

    • Immunology
    • Rheumatology

    Cite this

    Anti-DNA antibodies react with DNA expressed on the surface of monocytes and B lymphocytes. / Bennett, Robert (Rob); Davis, J.; Merritt, M.

    In: Journal of Rheumatology, Vol. 13, No. 4, 1986, p. 679-685.

    Research output: Contribution to journalArticle

    Bennett, Robert (Rob) ; Davis, J. ; Merritt, M. / Anti-DNA antibodies react with DNA expressed on the surface of monocytes and B lymphocytes. In: Journal of Rheumatology. 1986 ; Vol. 13, No. 4. pp. 679-685.
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