Anthropology of the apolipoprotein e (apo E) gene: Low frequency of apo E4 allele in Basques and in tribal (Baiga) populations of India

S. S. Mastana, R. Calderon, J. Pena, P. H. Reddy, S. S. Papiha

    Research output: Contribution to journalArticle

    32 Scopus citations

    Abstract

    The distribution of apolipoprotein E (apo E) polymorphism was examined in 11 population groups not previously studied for this system. There is a marked difference in phenotype and gene frequency between the populations of England and Spain. The south European populations of Basques and Spanish non-Basques showed greater similarity to the populations of South Asia. The study clearly indicates that the distribution of apo E alleles does match with regions showing a high mortality rate of coronary heart disease. The data presented also indicate that authochthon groups such as Basques in Europe and tribals in India may throw better light on the role of apolipoproteins in the regulation of lipid levels in disease.

    Original languageEnglish (US)
    Pages (from-to)137-143
    Number of pages7
    JournalAnnals of Human Biology
    Volume25
    Issue number2
    DOIs
    StatePublished - Jan 1 1998

    ASJC Scopus subject areas

    • Epidemiology
    • Physiology
    • Aging
    • Genetics
    • Public Health, Environmental and Occupational Health

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