Antesera to the ganglioside GM1 do not have anti-myelin or anti-axon activities in vitro

Dennis Bourdette, Bernard Zalc, Nicole Baumann, Frederick J. Seil

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Four antisera to the ganglioside GM1 were tested effects on myelin and axons when applied to mouse spinal cord-dorsal root ganglia explant cultures. None of the antisera to GM1 caused myelination inhibition or demyelination, while an antiserum tto galactocerebroside caused both. Antisera to GM1 did not axonal outgrowth or destroy mature outgrowth zone axons, while an anteserum to a rat brain axolemma-enriched fraction did both. These results suggest that antibodies to GM1 do not have significant anti-myelin or anti-axon activity.

Original languageEnglish (US)
Pages (from-to)175-180
Number of pages6
JournalBrain Research
Volume478
Issue number1
DOIs
StatePublished - Jan 23 1989

Fingerprint

G(M1) Ganglioside
Myelin Sheath
Axons
Immune Sera
Spinal Ganglia
Demyelinating Diseases
Spinal Cord
In Vitro Techniques
Antibodies
Brain

Keywords

  • Anti-axon antibody
  • Demyelination
  • Ganglioside antibody
  • Myelination inhibition
  • Tissue culture

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Antesera to the ganglioside GM1 do not have anti-myelin or anti-axon activities in vitro. / Bourdette, Dennis; Zalc, Bernard; Baumann, Nicole; Seil, Frederick J.

In: Brain Research, Vol. 478, No. 1, 23.01.1989, p. 175-180.

Research output: Contribution to journalArticle

Bourdette, Dennis ; Zalc, Bernard ; Baumann, Nicole ; Seil, Frederick J. / Antesera to the ganglioside GM1 do not have anti-myelin or anti-axon activities in vitro. In: Brain Research. 1989 ; Vol. 478, No. 1. pp. 175-180.
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