Abstract
Four antisera to the ganglioside GM1 were tested effects on myelin and axons when applied to mouse spinal cord-dorsal root ganglia explant cultures. None of the antisera to GM1 caused myelination inhibition or demyelination, while an antiserum tto galactocerebroside caused both. Antisera to GM1 did not axonal outgrowth or destroy mature outgrowth zone axons, while an anteserum to a rat brain axolemma-enriched fraction did both. These results suggest that antibodies to GM1 do not have significant anti-myelin or anti-axon activity.
Original language | English (US) |
---|---|
Pages (from-to) | 175-180 |
Number of pages | 6 |
Journal | Brain research |
Volume | 478 |
Issue number | 1 |
DOIs | |
State | Published - Jan 23 1989 |
Externally published | Yes |
Keywords
- Anti-axon antibody
- Demyelination
- Ganglioside antibody
- Myelination inhibition
- Tissue culture
ASJC Scopus subject areas
- General Neuroscience
- Molecular Biology
- Clinical Neurology
- Developmental Biology