Anterograde degeneration of the nigrostriatal pathway visualized by 123I-FP-CIT SPECT in a patient with artery of percheron infarction

Masashi Nakadate, Norikazu Miyamoto, Jay Starkey, Akira Toriihara, Ukihide Tateishi

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

123I-FP-CIT SPECT is widely used for diagnosis in patients with parkinsonism. Vascular parkinsonism usually has nonspecific findings from normal uptake to radiotracer decrease in the infarcted region. Infarction of the substantia nigra has been reported as a rare cause of vascular parkinsonism. We present a case of artery of Percheron infarction involving the substantia nigra unilaterally with ipsilateral reduction of striatal uptake on 123I-FP-CIT SPECT, suggesting anterograde degeneration of the nigrostriatal pathway. Infarction of the substantia nigra should be considered in cases of decreased striatal uptake with marked laterality on 123I-FP-CIT SPECT.

Original languageEnglish (US)
Pages (from-to)483-484
Number of pages2
JournalClinical Nuclear Medicine
Volume41
Issue number6
DOIs
StatePublished - Feb 24 2016
Externally publishedYes

Keywords

  • I-FP-CIT SPECT
  • Anterograde degeneration
  • Artery of Percheron infarction
  • Infarction of substantia nigra
  • Nigrostriatal pathway
  • Vascular parkinsonism

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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