@article{b55ffb19a84a418b8ac922cd212197c6,
title = "Anterior uveitis associated with high-dose cytosine arabinoside",
abstract = "Purpose:To report a case of anterior uveitis associated with high-dose cytosine arabinoside (Ara-C) treatment. Design:Observational case report. Methods:A 14-year-old girl was seen for pain, redness, and photophobia shortly after finishing a cycle of high-dose Ara-C. Results:Portable slit-lamp examination revealed bilateral diffuse fine keratic precipitates, indicative of a nongranulomatous anterior uveitis. This was treated successfully with a course of topical prednisolone acetate 1%. Conclusions:Ophthalmologists who are asked to evaluate patients on high-dose Ara-C for a {"}red eye{"} should consider anterior uveitis as a potential diagnosis.",
keywords = "Ara-C, anterior uveitis, cytosine arabinoside",
author = "Fintelmann, {Robert E.} and Ying Qian and Alison Skalet and Jeng, {Bennie H.}",
note = "Funding Information: Cytosine arabinoside (Ara-C) is an antimetabolite commonly used in the treatment of acute myeloid leukemia (AML),1 and it has been recently used as part of a new protocol in conjunction with gemtuzumab ozogamicin to treat de novo AML in children. (Trials identifier NCT00372593, sponsored by the National Cancer Institute; http://www.cancer.gov/ clinicaltrials/COG-AAML0531). Ara-C has been associated with ocular side effects in as many as 37% of patients,2 including corneal epithelial microcysts, conjunctivitis, and fine central corneal punctate opacities. To our knowledge, anterior uveitis associated with ara-C has been reported only rarely in the ophthalmic literature. Funding Information: Supported in part by a grant from That Man May See to the Department of Ophthalmology, University of California San Francisco Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper. Copyright: Copyright 2011 Elsevier B.V., All rights reserved.",
year = "2010",
month = dec,
doi = "10.3109/09273948.2010.510258",
language = "English (US)",
volume = "18",
pages = "485--487",
journal = "Ocular Immunology and Inflammation",
issn = "0927-3948",
publisher = "Informa Healthcare",
number = "6",
}