Anterior uveitis associated with high-dose cytosine arabinoside

Robert E. Fintelmann; Ying Qian; Alison Skalet; Bennie H. Jeng

doi:10.3109/09273948.2010.510258

Anterior uveitis associated with high-dose cytosine arabinoside

Robert E. Fintelmann, Ying Qian, Alison Skalet, Bennie H. Jeng

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Purpose:To report a case of anterior uveitis associated with high-dose cytosine arabinoside (Ara-C) treatment. Design:Observational case report. Methods:A 14-year-old girl was seen for pain, redness, and photophobia shortly after finishing a cycle of high-dose Ara-C. Results:Portable slit-lamp examination revealed bilateral diffuse fine keratic precipitates, indicative of a nongranulomatous anterior uveitis. This was treated successfully with a course of topical prednisolone acetate 1%. Conclusions:Ophthalmologists who are asked to evaluate patients on high-dose Ara-C for a "red eye" should consider anterior uveitis as a potential diagnosis.

Original language	English (US)
Pages (from-to)	485-487
Number of pages	3
Journal	Ocular Immunology and Inflammation
Volume	18
Issue number	6
DOIs	https://doi.org/10.3109/09273948.2010.510258
State	Published - Dec 2010
Externally published	Yes

Keywords

Ara-C
anterior uveitis
cytosine arabinoside

ASJC Scopus subject areas

Immunology and Allergy
Ophthalmology

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10.3109/09273948.2010.510258

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@article{b55ffb19a84a418b8ac922cd212197c6,

title = "Anterior uveitis associated with high-dose cytosine arabinoside",

abstract = "Purpose:To report a case of anterior uveitis associated with high-dose cytosine arabinoside (Ara-C) treatment. Design:Observational case report. Methods:A 14-year-old girl was seen for pain, redness, and photophobia shortly after finishing a cycle of high-dose Ara-C. Results:Portable slit-lamp examination revealed bilateral diffuse fine keratic precipitates, indicative of a nongranulomatous anterior uveitis. This was treated successfully with a course of topical prednisolone acetate 1%. Conclusions:Ophthalmologists who are asked to evaluate patients on high-dose Ara-C for a {"}red eye{"} should consider anterior uveitis as a potential diagnosis.",

keywords = "Ara-C, anterior uveitis, cytosine arabinoside",

author = "Fintelmann, {Robert E.} and Ying Qian and Alison Skalet and Jeng, {Bennie H.}",

note = "Funding Information: Cytosine arabinoside (Ara-C) is an antimetabolite commonly used in the treatment of acute myeloid leukemia (AML),1 and it has been recently used as part of a new protocol in conjunction with gemtuzumab ozogamicin to treat de novo AML in children. (Trials identifier NCT00372593, sponsored by the National Cancer Institute; http://www.cancer.gov/ clinicaltrials/COG-AAML0531). Ara-C has been associated with ocular side effects in as many as 37% of patients,2 including corneal epithelial microcysts, conjunctivitis, and fine central corneal punctate opacities. To our knowledge, anterior uveitis associated with ara-C has been reported only rarely in the ophthalmic literature.",

year = "2010",

month = dec,

doi = "10.3109/09273948.2010.510258",

language = "English (US)",

volume = "18",

pages = "485--487",

journal = "Ocular Immunology and Inflammation",

issn = "0927-3948",

publisher = "Informa Healthcare",

number = "6",

}

TY - JOUR

T1 - Anterior uveitis associated with high-dose cytosine arabinoside

AU - Fintelmann, Robert E.

AU - Qian, Ying

AU - Skalet, Alison

AU - Jeng, Bennie H.

N1 - Funding Information: Cytosine arabinoside (Ara-C) is an antimetabolite commonly used in the treatment of acute myeloid leukemia (AML),1 and it has been recently used as part of a new protocol in conjunction with gemtuzumab ozogamicin to treat de novo AML in children. (Trials identifier NCT00372593, sponsored by the National Cancer Institute; http://www.cancer.gov/ clinicaltrials/COG-AAML0531). Ara-C has been associated with ocular side effects in as many as 37% of patients,2 including corneal epithelial microcysts, conjunctivitis, and fine central corneal punctate opacities. To our knowledge, anterior uveitis associated with ara-C has been reported only rarely in the ophthalmic literature.

PY - 2010/12

Y1 - 2010/12

N2 - Purpose:To report a case of anterior uveitis associated with high-dose cytosine arabinoside (Ara-C) treatment. Design:Observational case report. Methods:A 14-year-old girl was seen for pain, redness, and photophobia shortly after finishing a cycle of high-dose Ara-C. Results:Portable slit-lamp examination revealed bilateral diffuse fine keratic precipitates, indicative of a nongranulomatous anterior uveitis. This was treated successfully with a course of topical prednisolone acetate 1%. Conclusions:Ophthalmologists who are asked to evaluate patients on high-dose Ara-C for a "red eye" should consider anterior uveitis as a potential diagnosis.

AB - Purpose:To report a case of anterior uveitis associated with high-dose cytosine arabinoside (Ara-C) treatment. Design:Observational case report. Methods:A 14-year-old girl was seen for pain, redness, and photophobia shortly after finishing a cycle of high-dose Ara-C. Results:Portable slit-lamp examination revealed bilateral diffuse fine keratic precipitates, indicative of a nongranulomatous anterior uveitis. This was treated successfully with a course of topical prednisolone acetate 1%. Conclusions:Ophthalmologists who are asked to evaluate patients on high-dose Ara-C for a "red eye" should consider anterior uveitis as a potential diagnosis.

KW - Ara-C

KW - anterior uveitis

KW - cytosine arabinoside

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Anterior uveitis associated with high-dose cytosine arabinoside

Abstract

Keywords

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