Anterior uveitis accompanies joint disease in a murine model resembling ankylosing spondylitis

Holly Rosenzweig, Tammy Martin, Stephen Planck, M. M. Jann, J. R. Smith, T. T. Glant, W. Van Eden, Michael Davey, James (Jim) Rosenbaum

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Uveitis is often associated with a systemic inflammatory disease such as ankylosing spondylitis. Our understanding of the eye's susceptibility to immune-mediated uveitis as in the apparent absence of infection has been limited by a relative lack of experimental models. Here we sought to assess whether ocular inflammation occurs in a previously described murine model of proteoglycan-induced spondylitis, wherein mice develop progressive spondylitis, sacroiliitis and peripheral arthritis - features common to the clinical presentations of ankylosing spondylitis. Methods: Using intravital microscopy we examined the ocular inflammatory response after the onset of arthritis in mice that overexpressed the T cell receptor (TCR) specific for a dominant arthritogenic epitope of cartilage proteoglycan [TCR-Tg (transgenic) mice] or BALB/c controls. Results: Immunized TCR-Tg mice showed a significant increase in the number of rolling and adhering cells within the iris vasculature compared to adjuvant control mice. Cellular infiltration within the iris tissue, as assessed by intravital microscopy and histology, was also increased. Our initial temporal analysis has revealed that immunized TCR-Tg mice show a significant increase in intravascular inflammation by 2 weeks after immunization, but it diminishes at 4 weeks after immunization. Conclusions: Although these data are preliminary, this model has the potential to clarify the mechanisms accounting for the coexistence of eye and sacroiliac inflammation as occurs in patients with ankylosing spondylitis.

Original languageEnglish (US)
Pages (from-to)189-192
Number of pages4
JournalOphthalmic Research
Volume40
Issue number3-4
DOIs
StatePublished - Apr 2008

Fingerprint

Anterior Uveitis
Joint Diseases
Ankylosing Spondylitis
T-Cell Antigen Receptor
Spondylitis
Uveitis
Iris
Proteoglycans
Inflammation
Arthritis
Immunization
Sacroiliitis
Transgenic Mice
Cartilage
Epitopes
Histology
Theoretical Models
Infection

Keywords

  • Ankylosing spondylitis
  • Murine
  • Uveitis

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Anterior uveitis accompanies joint disease in a murine model resembling ankylosing spondylitis. / Rosenzweig, Holly; Martin, Tammy; Planck, Stephen; Jann, M. M.; Smith, J. R.; Glant, T. T.; Van Eden, W.; Davey, Michael; Rosenbaum, James (Jim).

In: Ophthalmic Research, Vol. 40, No. 3-4, 04.2008, p. 189-192.

Research output: Contribution to journalArticle

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