TY - JOUR
T1 - Anterior chamber angle measurements using Schwalbe's line with high-resolution fourier-domain optical coherence tomography
AU - Qin, Bing
AU - Francis, Brian A.
AU - Li, Yan
AU - Tang, Maolong
AU - Zhang, Xinbo
AU - Jiang, Chunhui
AU - Cleary, Catherine
AU - Huang, David
PY - 2013/12
Y1 - 2013/12
N2 - PURPOSE:: To use Fourier-domain optical coherence tomography (OCT) to measure the angle opening distance at Schwalbe's line (AOD-SL) and determine its value in anterior chamber angle assessment. METHODS:: Horizontal scans of the nasal and temporal anterior chamber angles in glaucoma subjects were performed at 830 nm wavelength Fourier-domain OCT. Images were graded by 2 ophthalmologists who assessed the visibility of Schwalbe's line (SL), anterior limbus (AL), scleral spur (SS), and angle recess (AR). AOD-SL was measured with computer calipers. SL was manually identified by the termination of the corneal endothelium. Gonioscopy was used to classify anterior chamber angles according to a modified Shaffer system. Spearman ρ analysis was performed to assess correlation between AOD-SL and modified Shaffer grade. A cutoff value of AOD-SL for diagnosing occludable angles (modified Shaffer grade ≤1) was determined by receiver operating characteristic (ROC) analyses. RESULTS:: Thirty-five glaucoma subjects (65 eyes) were enrolled. SL, AL, AR, and SS were visible by OCT in 97.7%, 99.2%, 87.3%, and 80.8% of eyes, respectively. Nasal and temporal AOD-SLs were 322.6±200.2 μm and 341.4±197.4 μm, respectively. Correlation coefficients between AOD-SL and modified Shaffer grade were 0.80 (nasal) and 0.81 (temporal). The diagnostic cutoff value of AOD-SL for occludable angles was 290 μm. The areas under the ROC curve, sensitivity, specificity values were 0.90, 0.80, 0.87 (nasal) and 0.90, 0.85, 0.77 (temporal), respectively. CONCLUSIONS:: The measurement of AOD-SL by Fourier-domain OCT is highly correlated with gonioscopy and may be a useful noncontact method for assessing angle closure risk.
AB - PURPOSE:: To use Fourier-domain optical coherence tomography (OCT) to measure the angle opening distance at Schwalbe's line (AOD-SL) and determine its value in anterior chamber angle assessment. METHODS:: Horizontal scans of the nasal and temporal anterior chamber angles in glaucoma subjects were performed at 830 nm wavelength Fourier-domain OCT. Images were graded by 2 ophthalmologists who assessed the visibility of Schwalbe's line (SL), anterior limbus (AL), scleral spur (SS), and angle recess (AR). AOD-SL was measured with computer calipers. SL was manually identified by the termination of the corneal endothelium. Gonioscopy was used to classify anterior chamber angles according to a modified Shaffer system. Spearman ρ analysis was performed to assess correlation between AOD-SL and modified Shaffer grade. A cutoff value of AOD-SL for diagnosing occludable angles (modified Shaffer grade ≤1) was determined by receiver operating characteristic (ROC) analyses. RESULTS:: Thirty-five glaucoma subjects (65 eyes) were enrolled. SL, AL, AR, and SS were visible by OCT in 97.7%, 99.2%, 87.3%, and 80.8% of eyes, respectively. Nasal and temporal AOD-SLs were 322.6±200.2 μm and 341.4±197.4 μm, respectively. Correlation coefficients between AOD-SL and modified Shaffer grade were 0.80 (nasal) and 0.81 (temporal). The diagnostic cutoff value of AOD-SL for occludable angles was 290 μm. The areas under the ROC curve, sensitivity, specificity values were 0.90, 0.80, 0.87 (nasal) and 0.90, 0.85, 0.77 (temporal), respectively. CONCLUSIONS:: The measurement of AOD-SL by Fourier-domain OCT is highly correlated with gonioscopy and may be a useful noncontact method for assessing angle closure risk.
KW - anterior chamber angle imaging
KW - glaucoma
KW - optical coherence tomography
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U2 - 10.1097/IJG.0b013e318264b921
DO - 10.1097/IJG.0b013e318264b921
M3 - Article
C2 - 22827999
AN - SCOPUS:84890547873
SN - 1057-0829
VL - 22
SP - 684
EP - 688
JO - Journal of Glaucoma
JF - Journal of Glaucoma
IS - 9
ER -