Anomalies in network bridges involved in bile acid metabolism predict outcomes of colorectal cancer patients

Sunjae Lee, Ki Young Lee, Seyeol Yoon, Jae W. Lee, Doheon Lee

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Biomarkers prognostic for colorectal cancer (CRC) would be highly desirable in clinical practice. Proteins that regulate bile acid (BA) homeostasis, by linking metabolic sensors and metabolic enzymes, also called bridge proteins, may be reliable prognostic biomarkers for CRC. Based on a devised metric, "bridgeness," we identified bridge proteins involved in the regulation of BA homeostasis and identified their prognostic potentials. The expression patterns of these bridge proteins could distinguish between normal and diseased tissues, suggesting that these proteins are associated with CRC pathogenesis. Using a supervised classification system, we found that these bridge proteins were reproducibly prognostic, with high prognostic ability compared to other known markers.

Original languageEnglish (US)
Article numbere107925
JournalPloS one
Volume9
Issue number9
DOIs
StatePublished - Sep 26 2014

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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