Abstract
In experiments examining the potential reconsolidation of drug-associated contextual memories, rats were given a single pairing of cocaine with a specific context, and the ability of the protein synthesis inhibitor anisomycin administered following a context-only memory retrieval trial to impair conditioned locomotor sensitization was tested. Rats receiving 150 mg/kg anisomycin immediately following a 5-min reexposure to the cocaine-conditioned context showed decreased activity compared with the vehicle control group in response to a low-dose cocaine challenge during a subsequent test for conditioned sensitization. This effect was not seen when anisomycin was administered following a 30-min reexposure to the context or when anisomycin was administered 25 min after a 5-min reexposure. These results are consistent with a growing literature suggesting that following retrieval, associative contextual memories may undergo a transient protein synthesis-dependent reconsolidation phase that normally serves to maintain memory.
Original language | English (US) |
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Pages (from-to) | 156-163 |
Number of pages | 8 |
Journal | Behavioral Neuroscience |
Volume | 121 |
Issue number | 1 |
DOIs | |
State | Published - Feb 2007 |
Keywords
- Anisomycin
- Cocaine
- Contextual memory
- Memory
- Reconsolidation
- Sensitization
ASJC Scopus subject areas
- Behavioral Neuroscience