Animal models of uveal melanoma

H. E. Grossniklaus, S. Dithmar, Daniel Albert

Research output: Contribution to journalReview article

41 Citations (Scopus)

Abstract

Many attempts have been made to develop a suitable animal model to study more effectively the aetiology, pathogenesis, diagnosis and therapy of intraocular (uveal) melanoma. Uveal melanoma may spontaneously occur in some animals, including dogs, cats, horses, rats, mice, birds and fish. The histological features, metastatic behaviour and unpredictable nature of occurrence of these uncommon spontaneous tumours detract from their suitability as a model Several methods have been developed to induce intraocular melanoma chemically or by radiation in laboratory animals. Some of these induced tumours resemble human uveal melanoma, although the majority originate from the retinal pigment epithelium. Uveal proliferations have been biologically induced by feline leukaemia/sarcoma virus and simian virus 40, although the presence of virus In tumour cells and extraocular tumours resulting from shed virus detract from the utility of this model. Inoculation of tissue culture hamster, murine or human melanoma cells into animal eyes has the advantage that the inoculation site and size of inoculum can be controlled. Disadvantages include the immune suppression necessary for tumour growth in some models as well as the fact that many of the melanoma cell lines are of cutaneous origin. Transgenic murine models have been developed using the promoter region of the tyrosinase gene to target expression of oncogenes in melanin-producing cells. Spontaneous intraocular pigmented tumours and distant metastases may occur, although many, if not all, of the intraocular tumours arise in the retinal pigment epithelium. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish (US)
Pages (from-to)195-211
Number of pages17
JournalMelanoma Research
Volume10
Issue number3
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

Fingerprint

Animal Models
Melanoma
Neoplasms
Retinal Pigment Epithelium
Feline Sarcoma Viruses
Feline Leukemia Virus
Oncogenic Viruses
Simian virus 40
Monophenol Monooxygenase
Melanins
Laboratory Animals
Oncogenes
Genetic Promoter Regions
Cricetinae
Horses
Birds
Uveal melanoma
Fishes
Cats
Dogs

Keywords

  • Animal models
  • Choroid
  • Ciliary body
  • Iris
  • Metastasis
  • Uveal melanoma

ASJC Scopus subject areas

  • Oncology
  • Dermatology
  • Cancer Research

Cite this

Animal models of uveal melanoma. / Grossniklaus, H. E.; Dithmar, S.; Albert, Daniel.

In: Melanoma Research, Vol. 10, No. 3, 01.01.2000, p. 195-211.

Research output: Contribution to journalReview article

Grossniklaus, H. E. ; Dithmar, S. ; Albert, Daniel. / Animal models of uveal melanoma. In: Melanoma Research. 2000 ; Vol. 10, No. 3. pp. 195-211.
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