Animal models of chikungunya virus infection and disease

Nicole N. Haese, Rebecca M. Broeckel, David W. Hawman, Mark T. Heise, Thomas E. Morrison, Daniel Streblow

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Chikungunya virus (CHIKV) is a reemerging alphavirus that causes acute febrile illness and severe joint pain in humans. Although acute symptoms often resolve within a few days, chronic joint and muscle pain can be long lasting. In the last decade, CHIKV has caused widespread outbreaks of unprecedented scale in the Americas, Asia, and the Indian Ocean island regions. Despite these outbreaks and the continued expansion of CHIKV into new areas, mechanisms of chikungunya pathogenesis and disease are not well understood. Experimental animal models are indispensable to the field of CHIKV research. The most commonly used experimental animal models of CHIKV infection are mice and nonhuman primates; each model has its advantages for studying different aspects of CHIKV disease. This review will provide an overview of animal models used to study CHIKV infection and disease and major advances in our understanding of chikungunya obtained from studies performed in these models.

Original languageEnglish (US)
Pages (from-to)S482-S487
JournalJournal of Infectious Diseases
Volume214
DOIs
StatePublished - Dec 1 2016

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Chikungunya virus
Virus Diseases
Animal Models
Arthralgia
Disease Outbreaks
Indian Ocean Islands
Alphavirus
Myalgia
Chronic Pain
Primates
Fever
Chikungunya Fever
Research

Keywords

  • Alphavirus
  • Animal models
  • Chikungunya
  • Mouse models
  • Nonhuman primates

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Haese, N. N., Broeckel, R. M., Hawman, D. W., Heise, M. T., Morrison, T. E., & Streblow, D. (2016). Animal models of chikungunya virus infection and disease. Journal of Infectious Diseases, 214, S482-S487. https://doi.org/10.1093/infdis/jiw284

Animal models of chikungunya virus infection and disease. / Haese, Nicole N.; Broeckel, Rebecca M.; Hawman, David W.; Heise, Mark T.; Morrison, Thomas E.; Streblow, Daniel.

In: Journal of Infectious Diseases, Vol. 214, 01.12.2016, p. S482-S487.

Research output: Contribution to journalArticle

Haese, NN, Broeckel, RM, Hawman, DW, Heise, MT, Morrison, TE & Streblow, D 2016, 'Animal models of chikungunya virus infection and disease', Journal of Infectious Diseases, vol. 214, pp. S482-S487. https://doi.org/10.1093/infdis/jiw284
Haese, Nicole N. ; Broeckel, Rebecca M. ; Hawman, David W. ; Heise, Mark T. ; Morrison, Thomas E. ; Streblow, Daniel. / Animal models of chikungunya virus infection and disease. In: Journal of Infectious Diseases. 2016 ; Vol. 214. pp. S482-S487.
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