Animal models of age related macular degeneration

Mark Pennesi, Martha Neuringer, Robert J. Courtney

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

Age related macular degeneration (AMD) is the leading cause of vision loss of those over the age of 65 in the industrialized world. The prevalence and need to develop effective treatments for AMD has lead to the development of multiple animal models. AMD is a complex and heterogeneous disease that involves the interaction of both genetic and environmental factors with the unique anatomy of the human macula. Models in mice, rats, rabbits, pigs and non-human primates have recreated many of the histological features of AMD and provided much insight into the underlying pathological mechanisms of this disease. In spite of the large number of models developed, no one model yet recapitulates all of the features of human AMD. However, these models have helped reveal the roles of chronic oxidative damage, inflammation and immune dysregulation, and lipid metabolism in the development of AMD. Models for induced choroidal neovascularization have served as the backbone for testing new therapies. This article will review the diversity of animal models that exist for AMD as well as their strengths and limitations.

Original languageEnglish (US)
Pages (from-to)487-509
Number of pages23
JournalMolecular Aspects of Medicine
Volume33
Issue number4
DOIs
StatePublished - Aug 2012

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Macular Degeneration
Animals
Animal Models
Choroidal Neovascularization
Lipid Metabolism
Primates
Rats
Anatomy
Swine
Rabbits
Inflammation
Testing
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Molecular Medicine
  • Clinical Biochemistry
  • Medicine(all)

Cite this

Animal models of age related macular degeneration. / Pennesi, Mark; Neuringer, Martha; Courtney, Robert J.

In: Molecular Aspects of Medicine, Vol. 33, No. 4, 08.2012, p. 487-509.

Research output: Contribution to journalArticle

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