Animal models in HIV-1 protection and therapy

    Research output: Contribution to journalReview articlepeer-review

    40 Scopus citations


    Purpose of review The purpose of this review is to highlight major advances in the development and use of animal models for HIV-1 research during the last year. Recent findings Animal model research during the last year has focused on the development and refinement of models; use of these models to explore key questions about HIV entry, immune control, and persistence; and key discoveries with these models testing therapeutic and vaccine concepts. Some of the greatest breakthroughs have been in understanding early events surrounding transmission, the effectiveness of broadly neutralizing human monoclonal antibodies as passive prophylaxis, and some new ideas in the area of eliminating the viral reservoir in established infection. Summary Despite the lack of a flawless HIV-1 infection and pathogenesis model, the field utilizes several models that have already made important contributions to our understanding of early events, immune control, and the potential for novel therapies.

    Original languageEnglish (US)
    Pages (from-to)170-176
    Number of pages7
    JournalCurrent Opinion in HIV and AIDS
    Issue number3
    StatePublished - May 27 2015


    • HIV-1
    • Keywords animal models
    • humanized mice
    • nonhuman primate
    • simian immunodeficiency virus (SIV)
    • simian/human immunodeficiency virus (SHIV)

    ASJC Scopus subject areas

    • Immunology
    • Hematology
    • Oncology
    • Oncology(nursing)
    • Infectious Diseases
    • Virology


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