Animal models in HIV-1 protection and therapy

    Research output: Contribution to journalArticle

    27 Citations (Scopus)

    Abstract

    Purpose of review The purpose of this review is to highlight major advances in the development and use of animal models for HIV-1 research during the last year. Recent findings Animal model research during the last year has focused on the development and refinement of models; use of these models to explore key questions about HIV entry, immune control, and persistence; and key discoveries with these models testing therapeutic and vaccine concepts. Some of the greatest breakthroughs have been in understanding early events surrounding transmission, the effectiveness of broadly neutralizing human monoclonal antibodies as passive prophylaxis, and some new ideas in the area of eliminating the viral reservoir in established infection. Summary Despite the lack of a flawless HIV-1 infection and pathogenesis model, the field utilizes several models that have already made important contributions to our understanding of early events, immune control, and the potential for novel therapies.

    Original languageEnglish (US)
    Pages (from-to)170-176
    Number of pages7
    JournalCurrent Opinion in HIV and AIDS
    Volume10
    Issue number3
    DOIs
    StatePublished - May 27 2015

    Fingerprint

    HIV-1
    Animal Models
    HIV Infections
    Vaccines
    Monoclonal Antibodies
    HIV
    Therapeutics
    Infection
    Research

    Keywords

    • HIV-1
    • humanized mice
    • Keywords animal models
    • nonhuman primate
    • simian immunodeficiency virus (SIV)
    • simian/human immunodeficiency virus (SHIV)

    ASJC Scopus subject areas

    • Hematology
    • Oncology(nursing)
    • Immunology
    • Infectious Diseases
    • Virology
    • Oncology

    Cite this

    Animal models in HIV-1 protection and therapy. / Hessell, Ann; Haigwood, Nancy.

    In: Current Opinion in HIV and AIDS, Vol. 10, No. 3, 27.05.2015, p. 170-176.

    Research output: Contribution to journalArticle

    @article{8c5d94e0f9d3445ab7ede858b31d2ae0,
    title = "Animal models in HIV-1 protection and therapy",
    abstract = "Purpose of review The purpose of this review is to highlight major advances in the development and use of animal models for HIV-1 research during the last year. Recent findings Animal model research during the last year has focused on the development and refinement of models; use of these models to explore key questions about HIV entry, immune control, and persistence; and key discoveries with these models testing therapeutic and vaccine concepts. Some of the greatest breakthroughs have been in understanding early events surrounding transmission, the effectiveness of broadly neutralizing human monoclonal antibodies as passive prophylaxis, and some new ideas in the area of eliminating the viral reservoir in established infection. Summary Despite the lack of a flawless HIV-1 infection and pathogenesis model, the field utilizes several models that have already made important contributions to our understanding of early events, immune control, and the potential for novel therapies.",
    keywords = "HIV-1, humanized mice, Keywords animal models, nonhuman primate, simian immunodeficiency virus (SIV), simian/human immunodeficiency virus (SHIV)",
    author = "Ann Hessell and Nancy Haigwood",
    year = "2015",
    month = "5",
    day = "27",
    doi = "10.1097/COH.0000000000000152",
    language = "English (US)",
    volume = "10",
    pages = "170--176",
    journal = "Current Opinion in HIV and AIDS",
    issn = "1746-630X",
    publisher = "Lippincott Williams and Wilkins",
    number = "3",

    }

    TY - JOUR

    T1 - Animal models in HIV-1 protection and therapy

    AU - Hessell, Ann

    AU - Haigwood, Nancy

    PY - 2015/5/27

    Y1 - 2015/5/27

    N2 - Purpose of review The purpose of this review is to highlight major advances in the development and use of animal models for HIV-1 research during the last year. Recent findings Animal model research during the last year has focused on the development and refinement of models; use of these models to explore key questions about HIV entry, immune control, and persistence; and key discoveries with these models testing therapeutic and vaccine concepts. Some of the greatest breakthroughs have been in understanding early events surrounding transmission, the effectiveness of broadly neutralizing human monoclonal antibodies as passive prophylaxis, and some new ideas in the area of eliminating the viral reservoir in established infection. Summary Despite the lack of a flawless HIV-1 infection and pathogenesis model, the field utilizes several models that have already made important contributions to our understanding of early events, immune control, and the potential for novel therapies.

    AB - Purpose of review The purpose of this review is to highlight major advances in the development and use of animal models for HIV-1 research during the last year. Recent findings Animal model research during the last year has focused on the development and refinement of models; use of these models to explore key questions about HIV entry, immune control, and persistence; and key discoveries with these models testing therapeutic and vaccine concepts. Some of the greatest breakthroughs have been in understanding early events surrounding transmission, the effectiveness of broadly neutralizing human monoclonal antibodies as passive prophylaxis, and some new ideas in the area of eliminating the viral reservoir in established infection. Summary Despite the lack of a flawless HIV-1 infection and pathogenesis model, the field utilizes several models that have already made important contributions to our understanding of early events, immune control, and the potential for novel therapies.

    KW - HIV-1

    KW - humanized mice

    KW - Keywords animal models

    KW - nonhuman primate

    KW - simian immunodeficiency virus (SIV)

    KW - simian/human immunodeficiency virus (SHIV)

    UR - http://www.scopus.com/inward/record.url?scp=84928574709&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84928574709&partnerID=8YFLogxK

    U2 - 10.1097/COH.0000000000000152

    DO - 10.1097/COH.0000000000000152

    M3 - Article

    C2 - 25730345

    AN - SCOPUS:84928574709

    VL - 10

    SP - 170

    EP - 176

    JO - Current Opinion in HIV and AIDS

    JF - Current Opinion in HIV and AIDS

    SN - 1746-630X

    IS - 3

    ER -