Animal models for the genetic study of human alcohol phenotypes

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Researchers are increasingly using animal models to study the genetic basis of complex human behaviors, such as alcoholism. The most commonly used animal species are rodents, but other species, such as nonhuman primates, fruit flies, and zebrafish, can also provide important information. A variety of approaches are employed in these studies, particularly knockout and transgenic mice as well as specially bred animal lines that can be used for various genetic analyses, including quantitative trait locus mapping. Other strategies applied in genetic studies in animal models include random mutagenesis, virus-mediated gene transfer, and gene expression profiling.

Original languageEnglish (US)
Pages (from-to)202-207
Number of pages6
JournalAlcohol Research and Health
Volume26
Issue number3
StatePublished - Dec 1 2002

Keywords

  • Alcoholic beverage, phenotype
  • Animal model, gene knockout, transgenic technology
  • Gene expression
  • Genetic correlation analysis
  • Genetic theory of AODU (alcohol and other drug use)
  • Genetic trait
  • Mutagenesis
  • QTL (quantitative trait locus) mapping

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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