Animal models for the genetic study of human alcohol phenotypes

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Researchers are increasingly using animal models to study the genetic basis of complex human behaviors, such as alcoholism. The most commonly used animal species are rodents, but other species, such as nonhuman primates, fruit flies, and zebrafish, can also provide important information. A variety of approaches are employed in these studies, particularly knockout and transgenic mice as well as specially bred animal lines that can be used for various genetic analyses, including quantitative trait locus mapping. Other strategies applied in genetic studies in animal models include random mutagenesis, virus-mediated gene transfer, and gene expression profiling.

Original languageEnglish (US)
Pages (from-to)202-207
Number of pages6
JournalAlcohol Research and Health
Volume26
Issue number3
StatePublished - 2002

Fingerprint

Medical Genetics
Animal Models
Alcohols
Phenotype
Quantitative Trait Loci
Gene Expression Profiling
Zebrafish
Knockout Mice
Mutagenesis
Diptera
Primates
Transgenic Mice
Alcoholism
Rodentia
Fruit
Research Personnel
Viruses
Genes

Keywords

  • Alcoholic beverage, phenotype
  • Animal model, gene knockout, transgenic technology
  • Gene expression
  • Genetic correlation analysis
  • Genetic theory of AODU (alcohol and other drug use)
  • Genetic trait
  • Mutagenesis
  • QTL (quantitative trait locus) mapping

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Animal models for the genetic study of human alcohol phenotypes. / Phillips, Tamara.

In: Alcohol Research and Health, Vol. 26, No. 3, 2002, p. 202-207.

Research output: Contribution to journalArticle

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