Angiotensin II receptor subtypes in the rat brain

Brian P. Rowe, Kevin L. Grove, David L. Saylor, Robert C. Speth

    Research output: Contribution to journalArticlepeer-review

    108 Scopus citations


    The non-peptide angiotensin II (AII) receptor subtype selective antagonist, DuP 753, was used to characterize AII receptor binding sites in the rat brain. DuP 753 competed for specific 125I-[Sar1, Ile8]AII (125I-SIAII) binding in many brain nuclei (IC50 = 20-30 nM), but was a weak competitor at remaining sites (IC50 > 10-4 M). DuP 753 sensitive binding sites (designated AIIα subtype) correspond with areas where binding is inhibited by sulfhydryl reducing agents, whereas DuP 753 insensitive sites (AIIβ) correspond with areas where binding is not inhibited by sulfhydryl reducing agents.

    Original languageEnglish (US)
    Pages (from-to)339-342
    Number of pages4
    JournalEuropean Journal of Pharmacology
    Issue number2-3
    StatePublished - Sep 21 1990


    • (Rat)
    • (Receptor subtypes)
    • Angiotensin II receptors
    • Brain
    • DuP 753
    • Receptor autoradiography

    ASJC Scopus subject areas

    • Pharmacology


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