Angiotensin II receptor subtypes in the rat brain

Brian P. Rowe, Kevin L. Grove, David L. Saylor, Robert C. Speth

Research output: Contribution to journalArticlepeer-review

109 Scopus citations

Abstract

The non-peptide angiotensin II (AII) receptor subtype selective antagonist, DuP 753, was used to characterize AII receptor binding sites in the rat brain. DuP 753 competed for specific 125I-[Sar1, Ile8]AII (125I-SIAII) binding in many brain nuclei (IC50 = 20-30 nM), but was a weak competitor at remaining sites (IC50 > 10-4 M). DuP 753 sensitive binding sites (designated AIIα subtype) correspond with areas where binding is inhibited by sulfhydryl reducing agents, whereas DuP 753 insensitive sites (AIIβ) correspond with areas where binding is not inhibited by sulfhydryl reducing agents.

Original languageEnglish (US)
Pages (from-to)339-342
Number of pages4
JournalEuropean Journal of Pharmacology
Volume186
Issue number2-3
DOIs
StatePublished - Sep 21 1990
Externally publishedYes

Keywords

  • (Rat)
  • (Receptor subtypes)
  • Angiotensin II receptors
  • Brain
  • DuP 753
  • Receptor autoradiography

ASJC Scopus subject areas

  • Pharmacology

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