Angiotensin II receptor development in the bed nucleus of the stria terminalis and other perihypothalamic brain regions of the female and male rat

Kevin Grove, Vickie I. Cook, Robert C. Speth

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Brain angiotensin II (AII) receptors play a role in the regulation of luteinizing hormone release. This action is thought to involve luteinizing hormone-releasing hormone containing neurons in the preoptic-anterior hypothalamic (POAH) area of the brain. Previous studies have demonstrated a discrete locus of All receptor binding sites and responsiveness within the POAH to microinjections of All in the adult female rat, corresponding to the ventral portion of the bed nucleus of the stria terminalis (BSTV). To further characterize the age-and sex-dependent All receptor binding in the BSTV and other brain regions, in vitro receptor autoradiography using 125I-sarcosine1, isoleucine8 All (125I-SI All) was performed on 2-, 4- and 10-week-old female and male rat brains. Rats of both sexes displayed an age-dependent increase in 125I-S1 All binding in the BSTV, as well as in the suprachiasmatic nucleus (SCh). There was no detectable difference in binding within the BSTV between the female and male of any age group. Prepubertal ovariectomy did not impair the expression of 125I-Sl All binding in the BSTV or the SCh of adult female rats. The developmental expression of All receptors in the BSTV and SCh may therefore play a role in sexual maturation and regulation of sexual function in the rat.

Original languageEnglish (US)
Pages (from-to)169-177
Number of pages9
JournalNeuroendocrinology
Volume56
Issue number2
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Septal Nuclei
Angiotensin Receptors
Suprachiasmatic Nucleus
Brain
Anterior Hypothalamic Nucleus
Sexual Maturation
Microinjections
Ovariectomy
Luteinizing Hormone
Autoradiography
Gonadotropin-Releasing Hormone
Age Groups
Binding Sites
Neurons

Keywords

  • <sup>125</sup>I-sarcosine<sup>1</sup>
  • Angiotensin II receptors
  • Bed nucleus of the stria terminalis
  • Development
  • Female
  • Isoleucine<sup>8</sup>angiotensin II
  • Ovarian hormones
  • Rat
  • Receptor autoradiography
  • Suprachiasmatic nucleus

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems
  • Neuroscience(all)

Cite this

Angiotensin II receptor development in the bed nucleus of the stria terminalis and other perihypothalamic brain regions of the female and male rat. / Grove, Kevin; Cook, Vickie I.; Speth, Robert C.

In: Neuroendocrinology, Vol. 56, No. 2, 1992, p. 169-177.

Research output: Contribution to journalArticle

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