Angiotensin II and the locus coeruleus

R. C. Speth, Kevin Grove, B. P. Rowe

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The locus coeruleus (LC) is a putative site of action for angiotensin II in the brain. Immunocytochemical studies have identified angiotensin II-like immunoreactive material in nerve terminals innervating the LC, and the LC contains one of the highest densities of angiotensin II receptor binding sites in the rat brain. Recent studies using selective neurotoxins suggest that the binding sites for angiotensin II in the LC are present on noradrenergic perikarya. Angiotensin II receptors are now known to exist as two subtypes that are distinguishable both pharmacologically and biochemically. Radioligand binding studies using agonists and antagonists selective for these angiotensin II receptor subtypes indicate that the rat LC contains a mixture of the two known angiotensin II receptor subtypes, but that the PD123177-sensitive AII(β) receptor subtype is predominant. Comparisons of spontaneously hypertensive rats with normotensive rats indicates that angiotensin II and its receptors in the LC are elevated in the hypertensive rat strain. Studies of the biochemical and physiological actions of angiotensin II in the LC have not yet established an agreed-upon function for angiotensin II in this nucleus.

Original languageEnglish (US)
Pages (from-to)217-226
Number of pages10
JournalProgress in Brain Research
Volume88
StatePublished - 1991
Externally publishedYes

Fingerprint

Locus Coeruleus
Angiotensin II
Angiotensin Receptors
Binding Sites
Angiotensin II Type 1 Receptor Blockers
Neurotoxins
Brain
Inbred SHR Rats

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Speth, R. C., Grove, K., & Rowe, B. P. (1991). Angiotensin II and the locus coeruleus. Progress in Brain Research, 88, 217-226.

Angiotensin II and the locus coeruleus. / Speth, R. C.; Grove, Kevin; Rowe, B. P.

In: Progress in Brain Research, Vol. 88, 1991, p. 217-226.

Research output: Contribution to journalArticle

Speth, RC, Grove, K & Rowe, BP 1991, 'Angiotensin II and the locus coeruleus', Progress in Brain Research, vol. 88, pp. 217-226.
Speth RC, Grove K, Rowe BP. Angiotensin II and the locus coeruleus. Progress in Brain Research. 1991;88:217-226.
Speth, R. C. ; Grove, Kevin ; Rowe, B. P. / Angiotensin II and the locus coeruleus. In: Progress in Brain Research. 1991 ; Vol. 88. pp. 217-226.
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