Angiotensin II and the locus coeruleus

R. C. Speth, K. L. Grove, B. P. Rowe

    Research output: Chapter in Book/Report/Conference proceedingChapter

    12 Scopus citations

    Abstract

    The locus coeruleus (LC) is a putative site of action for angiotensin II in the brain. Immunocytochemical studies have identified angiotensin II-like immunoreactive material in nerve terminals innervating the LC, and the LC contains one of the highest densities of angiotensin II receptor binding sites in the rat brain. Recent studies using selective neurotoxins suggest that the binding sites for angiotensin II in the LC are present on noradrenergic perikarya. Angiotensin II receptors are now known to exist as two subtypes that are distinguishable both pharmacologically and biochemically. Radioligand binding studies using agonists and antagonists selective for these angiotensin II receptor subtypes indicate that the rat LC contains a mixture of the two known angiotensin II receptor subtypes, but that the PD123177-sensitive AIIβ receptor subtype is predominant. Comparisons of spontaneously hypertensive rats with normotensive rats indicates that angiotensin II and its receptors in the LC are elevated in the hypertensive rat strain. Studies of the biochemical and physiological actions of angiotensin II in the LC have not yet established an agreed-upon function for angiotensin II in this nucleus.

    Original languageEnglish (US)
    Title of host publicationProgress in Brain Research
    Pages217-226
    Number of pages10
    EditionC
    DOIs
    StatePublished - Jan 1 1991

    Publication series

    NameProgress in Brain Research
    NumberC
    Volume88
    ISSN (Print)0079-6123
    ISSN (Electronic)1875-7855

    Keywords

    • angiotensin receptors
    • blood pressure
    • brain renin-angiotensin system
    • receptor subtypes

    ASJC Scopus subject areas

    • Neuroscience(all)

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  • Cite this

    Speth, R. C., Grove, K. L., & Rowe, B. P. (1991). Angiotensin II and the locus coeruleus. In Progress in Brain Research (C ed., pp. 217-226). (Progress in Brain Research; Vol. 88, No. C). https://doi.org/10.1016/S0079-6123(08)63811-X