Angiotensin II

A reproductive hormone too?

R. C. Speth, D. L. Daubert, Kevin Grove

    Research output: Contribution to journalArticle

    64 Citations (Scopus)

    Abstract

    It has long been known that angiotensin II (Ang II) can affect reproductive tissues such as the uterus. However, the existence of a local renin-angiotensin system (RAS) in female as well as male reproductive tissues is a relatively recent observation. Of great interest is the discovery that all components of the RAS are present in the ovary, that the ovary secretes components of the RAS into the bloodstream, and that the ovary itself is responsive to Ang II. Recent studies suggest that the primary role of Ang II in the ovary is to cause atresia in non-ovulatory follicles; however, there is also compelling data to suggest that Ang II facilitates ovulation. Male reproductive structures also contain all of the components of the RAS, gonadotropins regulate the activity of these components, and these tissues have Ang II receptors. Of great interest is the expression of testis-specific angiotensin-converting enzyme (ACE), which is located on germ cells. Recent studies using gene knock-out techniques indicate that testis ACE plays an important role in male fertility. However, the overall significance of the RAS for normal reproductive function remains questionable. There is now a body of evidence implicating the RAS in pathophysiologies associated with reproductive function, which gives rise to the possibility that drugs acting on the RAS might ameliorate some of these disorders. Considerable work remains to determine the role of Ang II in reproductive functions. Copyright (C) 1999 Elsevier Science B.V.

    Original languageEnglish (US)
    Pages (from-to)25-40
    Number of pages16
    JournalRegulatory Peptides
    Volume79
    Issue number1
    DOIs
    StatePublished - Jan 1 1999

    Fingerprint

    Angiotensins
    Renin-Angiotensin System
    Renin
    Angiotensin II
    Hormones
    Ovary
    Peptidyl-Dipeptidase A
    Tissue
    Testis
    Gene Knockout Techniques
    Angiotensin Receptors
    Ovulation
    Gonadotropins
    Germ Cells
    Uterus
    Fertility
    Genes
    Cells
    Observation
    Pharmaceutical Preparations

    Keywords

    • Angiotensin II (Ang II)
    • Angiotensin II receptors
    • Angiotensin-converting enzyme (ACE)
    • Angiotensinogen (AON)
    • AT-1 angiotensin II receptor subtype (AT-1)
    • AT-2 angiotensin II receptor subtype (AT-2)
    • Cervix
    • Epididymis
    • Fallopian tube
    • Ovary
    • Prorenin
    • Renin
    • Renin-angiotensin system (RAS)
    • Spermatozoa
    • Testis
    • Uterus
    • Vas deferens

    ASJC Scopus subject areas

    • Biochemistry
    • Endocrinology
    • Physiology
    • Neuroscience(all)

    Cite this

    Angiotensin II : A reproductive hormone too? / Speth, R. C.; Daubert, D. L.; Grove, Kevin.

    In: Regulatory Peptides, Vol. 79, No. 1, 01.01.1999, p. 25-40.

    Research output: Contribution to journalArticle

    Speth, RC, Daubert, DL & Grove, K 1999, 'Angiotensin II: A reproductive hormone too?', Regulatory Peptides, vol. 79, no. 1, pp. 25-40. https://doi.org/10.1016/S0167-0115(98)00141-4
    Speth, R. C. ; Daubert, D. L. ; Grove, Kevin. / Angiotensin II : A reproductive hormone too?. In: Regulatory Peptides. 1999 ; Vol. 79, No. 1. pp. 25-40.
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