Angiotensin converting enzyme inhibitors and progressive renal insufficiency. Current experience and future directions

W. F. Keane, S. Anderson, M. Aurell, D. De Zeeuw, R. G. Narins, G. Povar

Research output: Contribution to journalReview article

143 Scopus citations


ACE inhibitors are tolerated by azotemic patients, although transient reductions in renal function can occur. Patients with bilateral renal insufficiency or low cardiac output are at increased risk for developing reversible acute renal insufficiency. Hyperkalemia may occur, particularly in patients with diabetes or severe renal insufficiency. In many patients with renal disease, ACE inhibitors dramatically reduce proteinuria, but whether they also reduce the rate of progression of renal disease remains unproved.

Original languageEnglish (US)
Pages (from-to)503-516
Number of pages14
JournalAnnals of internal medicine
Issue number6
StatePublished - Jan 1 1989


ASJC Scopus subject areas

  • Internal Medicine

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