Angiotensin-converting enzyme and cardiovascular disease risk

Jean Pruss O'Malley, Cheryl L. Maslen, D. Roger Illingworth

    Research output: Contribution to journalReview articlepeer-review

    23 Scopus citations


    The published studies of the association of the angiotensin-converting enzyme (ACE) genotype with cardiovascular disease have used many different diagnostic criteria for cardiovascular disease and have drawn their samples from different patient groups and different populations. This review examines the association of the ACE DD genotype with cardiovascular disease risk in studies grouped by their case criterion, the geographical region of the population samples, and by the cardiovascular risk level of the patient sample. In studies where the underlying odds ratios are determined to be homogeneous, the overall odds ratios for myocardial infarction and coronary artery disease with regard to the ACE DD genotype are estimated using the Mantel-Haenszel method.

    Original languageEnglish (US)
    Pages (from-to)407-415
    Number of pages9
    JournalCurrent opinion in lipidology
    Issue number5
    StatePublished - Dec 1 1999

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Molecular Biology
    • Genetics
    • Nutrition and Dietetics
    • Cardiology and Cardiovascular Medicine
    • Cell Biology


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