Angiogenesis in ovarian follicular and luteal development

Timothy M. Hazzard, Richard L. Stouffer

    Research output: Contribution to journalArticlepeer-review

    133 Scopus citations


    Angiogenesis is the process of new capillary formation from previously existing mature vessels. The adult ovary exhibits dramatic growth and regression of capillary networks on a cyclic basis. Ovarian follicles and the corpus luteum contain and produce endothelial cell-specific factors, which may act alone or in concert to regulate the process of angiogenesis. These factors are ultimately controlled by endocrine, paracrine and autocrine regulation, as well as by metabolic cellular signals such as intracellular oxygen content and ageing. Aberrant production of these angiogenic factors may be the cause of vascular dysfunction and the development of ovarian disorders. Recent technological advances for monitoring blood flow and measuring angiogenic factors could assist in accurately diagnosing ovarian disorders. Further elucidation of specific physiological role(s) of factors involved in angiogenesis of the pre-ovulatory follicle and developing corpus luteum may be useful in addressing issues of infertility in women.

    Original languageEnglish (US)
    Pages (from-to)883-900
    Number of pages18
    JournalBest Practice and Research: Clinical Obstetrics and Gynaecology
    Issue number6
    StatePublished - Jan 1 2000


    • Ageing, luteal phase defect
    • Angiogenesis
    • Angiopoietin
    • Fibroblast growth factor
    • Hypoxia
    • Luteinizing hormone
    • Ovarian hyperstimulation syndrome
    • Ovary
    • Polycystic ovarian syndrome
    • Ultrasound
    • Vascular endothelial growth factor

    ASJC Scopus subject areas

    • Obstetrics and Gynecology


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