Abstract
The epidemiology and histopathology of human cancers and studies of animal models of tumorigenesis have led to a widely-accepted notion that multiple genetic and epigenetic changes have to accrue for the successful development of a malignant phenotype. Tumor growth and expansion requires an ability not only to proliferate, but also to down-modulate cell death (apoptosis) and activate angiogenesis to produce a tumor neovasculature. This review will describe the interplay between apoptosis and proliferation, as well as the characteristics of the angiogenic phenotype in two transgenic mouse models of multi-step tumorigenesis, namely, pancreatic islet cell carcinomas and squamous cell carcinomas of the skin.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 995-1002 |
| Number of pages | 8 |
| Journal | International Journal of Developmental Biology |
| Volume | 42 |
| Issue number | 7 |
| State | Published - 1998 |
| Externally published | Yes |
Keywords
- Gene knockout
- Growth
- Growth factors
- Hormones
- Mouse embryo
ASJC Scopus subject areas
- Embryology
- Developmental Biology