Angiogenesis and apoptosis are cellular parameters of neoplastic progression in transgenic mouse models of tumorigenesis

Gabriele Bergers, Douglas Hanahan, Lisa Coussens

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

The epidemiology and histopathology of human cancers and studies of animal models of tumorigenesis have led to a widely-accepted notion that multiple genetic and epigenetic changes have to accrue for the successful development of a malignant phenotype. Tumor growth and expansion requires an ability not only to proliferate, but also to down-modulate cell death (apoptosis) and activate angiogenesis to produce a tumor neovasculature. This review will describe the interplay between apoptosis and proliferation, as well as the characteristics of the angiogenic phenotype in two transgenic mouse models of multi-step tumorigenesis, namely, pancreatic islet cell carcinomas and squamous cell carcinomas of the skin.

Original languageEnglish (US)
Pages (from-to)995-1002
Number of pages8
JournalInternational Journal of Developmental Biology
Volume42
Issue number7
StatePublished - 1998
Externally publishedYes

Fingerprint

Transgenic Mice
Carcinogenesis
Apoptosis
Islet Cell Carcinoma
Phenotype
Neoplasms
Islets of Langerhans
Epigenomics
Squamous Cell Carcinoma
Epidemiology
Cell Death
Animal Models
Skin
Growth

Keywords

  • Gene knockout
  • Growth
  • Growth factors
  • Hormones
  • Mouse embryo

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Angiogenesis and apoptosis are cellular parameters of neoplastic progression in transgenic mouse models of tumorigenesis. / Bergers, Gabriele; Hanahan, Douglas; Coussens, Lisa.

In: International Journal of Developmental Biology, Vol. 42, No. 7, 1998, p. 995-1002.

Research output: Contribution to journalArticle

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