Angiogenesis and apoptosis are cellular parameters of neoplastic progression in transgenic mouse models of tumorigenesis

Gabriele Bergers, Douglas Hanahan, Lisa Coussens

Research output: Contribution to journalArticle

70 Scopus citations


The epidemiology and histopathology of human cancers and studies of animal models of tumorigenesis have led to a widely-accepted notion that multiple genetic and epigenetic changes have to accrue for the successful development of a malignant phenotype. Tumor growth and expansion requires an ability not only to proliferate, but also to down-modulate cell death (apoptosis) and activate angiogenesis to produce a tumor neovasculature. This review will describe the interplay between apoptosis and proliferation, as well as the characteristics of the angiogenic phenotype in two transgenic mouse models of multi-step tumorigenesis, namely, pancreatic islet cell carcinomas and squamous cell carcinomas of the skin.

Original languageEnglish (US)
Pages (from-to)995-1002
Number of pages8
JournalInternational Journal of Developmental Biology
Issue number7
Publication statusPublished - 1998
Externally publishedYes



  • Gene knockout
  • Growth
  • Growth factors
  • Hormones
  • Mouse embryo

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this