Anesthetic Neurotoxicity

Ansgar M. Brambrink; Andrea Orfanakis; Jeffrey R. Kirsch

doi:10.1016/j.anclin.2012.06.002

Anesthetic Neurotoxicity

Ansgar M. Brambrink, Andrea Orfanakis, Jeffrey R. Kirsch

Research output: Contribution to journal › Review article › peer-review

42 Scopus citations

Abstract

Concerns for toxic effects of anesthesia to the brains of the young and the elderly are mounting. While experimental evidence for such effects in the developing brain is strong, the underlying mechanisms are less well understood and debate continues as to whether young humans are at risk for anesthetic neurotoxicity. The phenomenon of postoperative cognitive deterioration in the elderly remains controversial. Time course, severity, and whether or not it persists long term are under debate. For both patient groups, today's evidence is not sufficient to guide change in clinical practice. Well-designed research is therefore imperative to tackle this critical issue.

Original language	English (US)
Pages (from-to)	207-228
Number of pages	22
Journal	Anesthesiology Clinics
Volume	30
Issue number	2
DOIs	https://doi.org/10.1016/j.anclin.2012.06.002
State	Published - Jun 2012
Externally published	Yes

Keywords

Aging brain
Anesthetics
Developing brain
Neurotoxicity

ASJC Scopus subject areas

Anesthesiology and Pain Medicine

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10.1016/j.anclin.2012.06.002

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title = "Anesthetic Neurotoxicity",

abstract = "Concerns for toxic effects of anesthesia to the brains of the young and the elderly are mounting. While experimental evidence for such effects in the developing brain is strong, the underlying mechanisms are less well understood and debate continues as to whether young humans are at risk for anesthetic neurotoxicity. The phenomenon of postoperative cognitive deterioration in the elderly remains controversial. Time course, severity, and whether or not it persists long term are under debate. For both patient groups, today's evidence is not sufficient to guide change in clinical practice. Well-designed research is therefore imperative to tackle this critical issue.",

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AU - Orfanakis, Andrea

AU - Kirsch, Jeffrey R.

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AB - Concerns for toxic effects of anesthesia to the brains of the young and the elderly are mounting. While experimental evidence for such effects in the developing brain is strong, the underlying mechanisms are less well understood and debate continues as to whether young humans are at risk for anesthetic neurotoxicity. The phenomenon of postoperative cognitive deterioration in the elderly remains controversial. Time course, severity, and whether or not it persists long term are under debate. For both patient groups, today's evidence is not sufficient to guide change in clinical practice. Well-designed research is therefore imperative to tackle this critical issue.

KW - Aging brain

KW - Anesthetics

KW - Developing brain

KW - Neurotoxicity

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Anesthetic Neurotoxicity

Abstract

Keywords

ASJC Scopus subject areas

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