Anesthetic Neurotoxicity

Ansgar M. Brambrink, Andrea Orfanakis, Jeffrey R. Kirsch

Research output: Contribution to journalReview article

31 Scopus citations

Abstract

Concerns for toxic effects of anesthesia to the brains of the young and the elderly are mounting. While experimental evidence for such effects in the developing brain is strong, the underlying mechanisms are less well understood and debate continues as to whether young humans are at risk for anesthetic neurotoxicity. The phenomenon of postoperative cognitive deterioration in the elderly remains controversial. Time course, severity, and whether or not it persists long term are under debate. For both patient groups, today's evidence is not sufficient to guide change in clinical practice. Well-designed research is therefore imperative to tackle this critical issue.

Original languageEnglish (US)
Pages (from-to)207-228
Number of pages22
JournalAnesthesiology Clinics
Volume30
Issue number2
DOIs
StatePublished - Jun 1 2012

Keywords

  • Aging brain
  • Anesthetics
  • Developing brain
  • Neurotoxicity

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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