Abstract
We measured cerebral blood flow and somatosensory evoked potentials during transient focal cerebral ischemia in cats to compare the effects of four commonly used anesthetic regimens: ketamine/fentanyl/N2O (fentanyl), pentobarbital, ketamine/α-chloralose (a-chloralose), and ketamine/halothane/N2O (halothane). Six cats in each group were subjected to 60 minutes of left middle cerebral artery occlusion followed by 120 minutes of reperfusion. Although the amplitude of the initial somatosensory evoked potential wave complex was highest in the tt-chloralose group (58.6±16.5 µV)and smallest in the halothane group (27.5±5.7 µV), amplitude fell by 75% in all groups upon occlusion. Baseline cerebral blood flow varied substantially between groups (e.g., in the right intersylvian gyrus: fentanyl, 96±12; pentobarbital, 30±5; α-chloralose, 24±3; and halothane, 76±11 ml/min/100 g). Occlusion decreased cerebral blood flow to subcortical (e.g., left caudate) structures in all groups (fentanyl, 29 ±11%; pentobabital, 45±12%; α-chloralose, 27±13%; and halothane, 18±5% of baseline). Postisch-emic hyperemia occurred in the cortical regions of cats anesthetized with pentobarbital or «-chloralose that had reduced cerebral blood flows during occlusion but not in cats anesthetized with fentanyl (cerebral blood flow during occlusion not different from that of cats anesthetized with pentobarbital or
| Original language | English (US) |
|---|---|
| Pages (from-to) | 795-800 |
| Number of pages | 6 |
| Journal | Stroke |
| Volume | 21 |
| Issue number | 5 |
| State | Published - 1990 |
| Externally published | Yes |
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Keywords
- Anesthesia
- Cats
- Cerebral ischemia
- Evoked potentials
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Clinical Neurology
- Advanced and Specialized Nursing
- Neuroscience(all)
Cite this
Anesthetic modulation of cerebral hemodynamic and evoked responses to transient middle cerebral artery occlusion in cats. / Helfaer, Mark A.; Kirsch, Jeffrey; Traystman, Richard J.
In: Stroke, Vol. 21, No. 5, 1990, p. 795-800.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Anesthetic modulation of cerebral hemodynamic and evoked responses to transient middle cerebral artery occlusion in cats
AU - Helfaer, Mark A.
AU - Kirsch, Jeffrey
AU - Traystman, Richard J.
PY - 1990
Y1 - 1990
N2 - We measured cerebral blood flow and somatosensory evoked potentials during transient focal cerebral ischemia in cats to compare the effects of four commonly used anesthetic regimens: ketamine/fentanyl/N2O (fentanyl), pentobarbital, ketamine/α-chloralose (a-chloralose), and ketamine/halothane/N2O (halothane). Six cats in each group were subjected to 60 minutes of left middle cerebral artery occlusion followed by 120 minutes of reperfusion. Although the amplitude of the initial somatosensory evoked potential wave complex was highest in the tt-chloralose group (58.6±16.5 µV)and smallest in the halothane group (27.5±5.7 µV), amplitude fell by 75% in all groups upon occlusion. Baseline cerebral blood flow varied substantially between groups (e.g., in the right intersylvian gyrus: fentanyl, 96±12; pentobarbital, 30±5; α-chloralose, 24±3; and halothane, 76±11 ml/min/100 g). Occlusion decreased cerebral blood flow to subcortical (e.g., left caudate) structures in all groups (fentanyl, 29 ±11%; pentobabital, 45±12%; α-chloralose, 27±13%; and halothane, 18±5% of baseline). Postisch-emic hyperemia occurred in the cortical regions of cats anesthetized with pentobarbital or «-chloralose that had reduced cerebral blood flows during occlusion but not in cats anesthetized with fentanyl (cerebral blood flow during occlusion not different from that of cats anesthetized with pentobarbital or
AB - We measured cerebral blood flow and somatosensory evoked potentials during transient focal cerebral ischemia in cats to compare the effects of four commonly used anesthetic regimens: ketamine/fentanyl/N2O (fentanyl), pentobarbital, ketamine/α-chloralose (a-chloralose), and ketamine/halothane/N2O (halothane). Six cats in each group were subjected to 60 minutes of left middle cerebral artery occlusion followed by 120 minutes of reperfusion. Although the amplitude of the initial somatosensory evoked potential wave complex was highest in the tt-chloralose group (58.6±16.5 µV)and smallest in the halothane group (27.5±5.7 µV), amplitude fell by 75% in all groups upon occlusion. Baseline cerebral blood flow varied substantially between groups (e.g., in the right intersylvian gyrus: fentanyl, 96±12; pentobarbital, 30±5; α-chloralose, 24±3; and halothane, 76±11 ml/min/100 g). Occlusion decreased cerebral blood flow to subcortical (e.g., left caudate) structures in all groups (fentanyl, 29 ±11%; pentobabital, 45±12%; α-chloralose, 27±13%; and halothane, 18±5% of baseline). Postisch-emic hyperemia occurred in the cortical regions of cats anesthetized with pentobarbital or «-chloralose that had reduced cerebral blood flows during occlusion but not in cats anesthetized with fentanyl (cerebral blood flow during occlusion not different from that of cats anesthetized with pentobarbital or
KW - Anesthesia
KW - Cats
KW - Cerebral ischemia
KW - Evoked potentials
UR - http://www.scopus.com/inward/record.url?scp=0025314977&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025314977&partnerID=8YFLogxK
M3 - Article
VL - 21
SP - 795
EP - 800
JO - Stroke
JF - Stroke
SN - 0039-2499
IS - 5
ER -