Anesthetic efficacy of the intraosseous injection of 2% lidocaine (1: 100,000 epinephrine) and 3% mepivacaine in mandibular first molars

Karan Replogle, Al Reader, Robert Nist, Mike Beck, Joel Weaver, William J. Meyers

Research output: Contribution to journalArticle

40 Scopus citations


Objectives. This study compared the anesthetic efficacy of a primary intraosseous injection of 2% lidocaine with 1:100,000 epinephrine and 3% mepivacaine in human mandibular first molars. Injection pain and healing postoperatively were also assessed for the intraosseous injection. Study design. With the use of a repeated-measures design, 42 subjects randomly received intraosseous injections of 1.8 ml of 2% lidocaine with 1:100,000 epinephrine or 1.8 ml of 3% mepivacaine in a double-blind manner at two successive appointments. The first molar and adjacent teeth were blindly tested with an electric pulp tester at 2-minute cycles for 60 minutes. Anesthetic success was defined as no subject response to the maximum output of the pulp tester (80 reading) for two consecutive readings. Results. Anesthetic success occurred in 74% of the first molars with 2% lidocaine with 1:100,000 epinephrine and in 45% with 3% mepivacaine. The difference was statistically significant (p < 0.05). Overall, onset was rapid for the intraosseous injections, the duration of pulpal anesthesia steadily declined over the 60 minutes, the majority of the subjects had no pain or mild pain with perforation and solution deposition, and 5% of the subjects had delayed healing at the perforation sites. Conclusions. The results of this study indicate that the primary intraosseous injection of 2% lidocaine with 1:100,000 epinephrine is more successful and results in a longer duration of pulpal anesthesia as compared with 3% mepivacaine in noninflamed mandibular first molars. Most subjects reported no or mild pain during perforation and injection.

Original languageEnglish (US)
Pages (from-to)30-37
Number of pages8
JournalOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Issue number1
Publication statusPublished - 1997
Externally publishedYes


ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Radiology Nuclear Medicine and imaging
  • Surgery
  • Dentistry(all)

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