Anesthetic agents and sympatho-adrenal response to hemorrhage in the rat

B. Hamberger, L. Bengtsson, Per-Olof Järnberg, L. O. Farnebo

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Abstract

The sympatho-adrenal activity as reflected in plasma catecholamine levels was studied in rats subjected to a standardized hemorrhage. A comparison was performed between awake rats and rats anesthetized with diethylether, enflurane, barbiturate or ketamine. As expected diethylether increased sympathoadrenal activity. Enflurane induction increased adrenaline and decreased noradrenaline levels. Upon hemorrhage the sympathoadrenal activity was depressed compared to the awake state. Barbiturate anesthesia depressed sympatho-adrenal activity. Ketamine increased noradrenaline levels and a relative hypertension was noticed during bleeding. The results focuse attention on important differences in sympatho-adrenal activity between awake rats and rats anesthetized with different agents.

Original languageEnglish (US)
Pages (from-to)109-113
Number of pages5
JournalActa Chirurgica Scandinavica
Volume150
Issue numberSUPPL. 520
Publication statusPublished - 1984
Externally publishedYes

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ASJC Scopus subject areas

  • Surgery

Cite this

Hamberger, B., Bengtsson, L., Järnberg, P-O., & Farnebo, L. O. (1984). Anesthetic agents and sympatho-adrenal response to hemorrhage in the rat. Acta Chirurgica Scandinavica, 150(SUPPL. 520), 109-113.