Anemia ameliorates progressive renal injury in experimental DOCA-salt hypertension

Helen M. Lafferty, Diego L. Garcia, Helmut G. Rennke, Julia L. Troy, Sharon Anderson, Barry M. Brenner

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


To explore the role of systemic hematocrit in the vascular adaptations which characterize desoxycorticosterone-salt hypertension, studies were performed in three groups of rats with uninephrectomy, desoxycorticosterone administration, and 1% saline in the drinking water. One group received recombinant human erythropoietin to increase hematocrit, and another group was subjected to phlebotomy and fed a low-iron diet to induce anemia. Control rats exhibited systemic and glomerular capillary hypertension, proteinuria, and substantial glomerular sclerosis at 8 wk. Erythropoietin modestly increased hematocrit and blood pressure and substantially aggravated glomerular capillary pressure, proteinuria, and glomerular sclerosis. In contrast, reduction ot hematocrit with a low-iron diet significantly attenuated systemic and glomerular hypertension, proteinuria, and sclerosis. It was concluded that the pace of progression of glomerular injury can be limited by chronic reduction in hematocrit, which effectively ameliorates both systemic and glomerular hypertension in this model of salt-sensitive hypertensive renal disease.

Original languageEnglish (US)
Pages (from-to)1180-1185
Number of pages6
JournalJournal of the American Society of Nephrology
Issue number10
StatePublished - Apr 1991
Externally publishedYes


  • Chronic renal failure
  • Hematocrit
  • Hemodynamics
  • Proteinuria

ASJC Scopus subject areas

  • Nephrology


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