Androgens and Bone

Basic Aspects

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The specific mechanisms by which androgens affect skeletal homeostasis, and whether these effects are directly mediated in bone, are areas of intensified research. As a classic steroid hormone, the biological cellular signaling responses to androgen are mediated through the androgen receptor (AR), a ligand-inducible transcription factor. ARs have been identified in a variety of cells found in bone and the characterization of AR expression in these cells thus clearly identifies bone as a target tissue for androgen action. The direct effects of androgen that influence the complex processes of proliferation, differentiation, mineralization and gene expression in the osteoblast are being characterized, but much remains to be established. Androgen effects on bone may also be indirectly modulated and/or mediated by other autocrine and paracrine factors in the bone microenvironment. This chapter reviews recent progress on the characterization of androgen action in bone.

Original languageEnglish (US)
Title of host publicationOsteoporosis in Men
PublisherElsevier Inc.
Pages295-317
Number of pages23
ISBN (Print)9780123746023
DOIs
StatePublished - 2010

Fingerprint

Androgens
Bone
Bone and Bones
Androgen Receptors
Steroid hormones
Cell signaling
Osteoblasts
Gene expression
Homeostasis
Transcription Factors
Steroids
Hormones
Tissue
Ligands
Gene Expression
Research

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Androgens and Bone : Basic Aspects. / Wiren, Kristine; Orwoll, Eric.

Osteoporosis in Men. Elsevier Inc., 2010. p. 295-317.

Research output: Chapter in Book/Report/Conference proceedingChapter

Wiren, Kristine ; Orwoll, Eric. / Androgens and Bone : Basic Aspects. Osteoporosis in Men. Elsevier Inc., 2010. pp. 295-317
@inbook{c259395f8551439785266b4b33fd6379,
title = "Androgens and Bone: Basic Aspects",
abstract = "The specific mechanisms by which androgens affect skeletal homeostasis, and whether these effects are directly mediated in bone, are areas of intensified research. As a classic steroid hormone, the biological cellular signaling responses to androgen are mediated through the androgen receptor (AR), a ligand-inducible transcription factor. ARs have been identified in a variety of cells found in bone and the characterization of AR expression in these cells thus clearly identifies bone as a target tissue for androgen action. The direct effects of androgen that influence the complex processes of proliferation, differentiation, mineralization and gene expression in the osteoblast are being characterized, but much remains to be established. Androgen effects on bone may also be indirectly modulated and/or mediated by other autocrine and paracrine factors in the bone microenvironment. This chapter reviews recent progress on the characterization of androgen action in bone.",
author = "Kristine Wiren and Eric Orwoll",
year = "2010",
doi = "10.1016/B978-0-12-374602-3.00025-0",
language = "English (US)",
isbn = "9780123746023",
pages = "295--317",
booktitle = "Osteoporosis in Men",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Androgens and Bone

T2 - Basic Aspects

AU - Wiren, Kristine

AU - Orwoll, Eric

PY - 2010

Y1 - 2010

N2 - The specific mechanisms by which androgens affect skeletal homeostasis, and whether these effects are directly mediated in bone, are areas of intensified research. As a classic steroid hormone, the biological cellular signaling responses to androgen are mediated through the androgen receptor (AR), a ligand-inducible transcription factor. ARs have been identified in a variety of cells found in bone and the characterization of AR expression in these cells thus clearly identifies bone as a target tissue for androgen action. The direct effects of androgen that influence the complex processes of proliferation, differentiation, mineralization and gene expression in the osteoblast are being characterized, but much remains to be established. Androgen effects on bone may also be indirectly modulated and/or mediated by other autocrine and paracrine factors in the bone microenvironment. This chapter reviews recent progress on the characterization of androgen action in bone.

AB - The specific mechanisms by which androgens affect skeletal homeostasis, and whether these effects are directly mediated in bone, are areas of intensified research. As a classic steroid hormone, the biological cellular signaling responses to androgen are mediated through the androgen receptor (AR), a ligand-inducible transcription factor. ARs have been identified in a variety of cells found in bone and the characterization of AR expression in these cells thus clearly identifies bone as a target tissue for androgen action. The direct effects of androgen that influence the complex processes of proliferation, differentiation, mineralization and gene expression in the osteoblast are being characterized, but much remains to be established. Androgen effects on bone may also be indirectly modulated and/or mediated by other autocrine and paracrine factors in the bone microenvironment. This chapter reviews recent progress on the characterization of androgen action in bone.

UR - http://www.scopus.com/inward/record.url?scp=84882844487&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882844487&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-374602-3.00025-0

DO - 10.1016/B978-0-12-374602-3.00025-0

M3 - Chapter

SN - 9780123746023

SP - 295

EP - 317

BT - Osteoporosis in Men

PB - Elsevier Inc.

ER -