Androgen receptors in a Syrian hamster ductus deferens tumour cell line

James S. Norris; Jack Gorski; Peter O. Kohler

doi:10.1038/248422a0

Androgen receptors in a Syrian hamster ductus deferens tumour cell line

James S. Norris, Jack Gorski, Peter O. Kohler

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Abstract

WE have established in culture a cloned line of hamster ductus deferens cells that contains a saturable, high affinity testosterone receptor protein. These cells exhibit an increased rate of DNA synthesis in response to testosterone and 5α-dihydrotestosterone (DHT) treatment, although they probably do not require either androgen for survival. We believe this is the first description of a cloned cell line that exhibits a growth response to a physiological dose of androgen. The mechanism of action of the steroid may be similar to that in the normal tissue of origin.

Original language	English (US)
Pages (from-to)	422-424
Number of pages	3
Journal	Nature
Volume	248
Issue number	5447
DOIs	https://doi.org/10.1038/248422a0
State	Published - 1974
Externally published	Yes

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abstract = "WE have established in culture a cloned line of hamster ductus deferens cells that contains a saturable, high affinity testosterone receptor protein. These cells exhibit an increased rate of DNA synthesis in response to testosterone and 5α-dihydrotestosterone (DHT) treatment, although they probably do not require either androgen for survival. We believe this is the first description of a cloned cell line that exhibits a growth response to a physiological dose of androgen. The mechanism of action of the steroid may be similar to that in the normal tissue of origin.",

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AU - Gorski, Jack

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AB - WE have established in culture a cloned line of hamster ductus deferens cells that contains a saturable, high affinity testosterone receptor protein. These cells exhibit an increased rate of DNA synthesis in response to testosterone and 5α-dihydrotestosterone (DHT) treatment, although they probably do not require either androgen for survival. We believe this is the first description of a cloned cell line that exhibits a growth response to a physiological dose of androgen. The mechanism of action of the steroid may be similar to that in the normal tissue of origin.

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Androgen receptors in a Syrian hamster ductus deferens tumour cell line

Abstract

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