Androgen receptors in a Syrian hamster ductus deferens tumour cell line

James S. Norris, Jack Gorski, Peter Kohler

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

WE have established in culture a cloned line of hamster ductus deferens cells that contains a saturable, high affinity testosterone receptor protein. These cells exhibit an increased rate of DNA synthesis in response to testosterone and 5α-dihydrotestosterone (DHT) treatment, although they probably do not require either androgen for survival. We believe this is the first description of a cloned cell line that exhibits a growth response to a physiological dose of androgen. The mechanism of action of the steroid may be similar to that in the normal tissue of origin.

Original languageEnglish (US)
Pages (from-to)422-424
Number of pages3
JournalNature
Volume248
Issue number5447
DOIs
StatePublished - 1974
Externally publishedYes

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Vas Deferens
Mesocricetus
Androgen Receptors
Tumor Cell Line
Androgens
Dihydrotestosterone
Cricetinae
Testosterone
Steroids
Cell Line
DNA
Growth
Proteins

ASJC Scopus subject areas

  • General

Cite this

Androgen receptors in a Syrian hamster ductus deferens tumour cell line. / Norris, James S.; Gorski, Jack; Kohler, Peter.

In: Nature, Vol. 248, No. 5447, 1974, p. 422-424.

Research output: Contribution to journalArticle

Norris, James S. ; Gorski, Jack ; Kohler, Peter. / Androgen receptors in a Syrian hamster ductus deferens tumour cell line. In: Nature. 1974 ; Vol. 248, No. 5447. pp. 422-424.
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