Anatomy and flow in normal and ischemic microvasculature based on a novel temporal fractal dimension analysis algorithm using contrast enhanced ultrasound

Dimitrios Charalampidis, Marco Pascotto, Edmund Kenneth Kerut, Jonathan R. Lindner

    Research output: Contribution to journalArticle

    11 Scopus citations


    Strategies for improvement of blood flow by promoting new vessel growth in ischemic tissue are being developed. Recently, contrast-enhanced ultrasound (CEU) imaging has been used to assess tissue perfusion in models of ischemia-related angiogenesis, growth-factor mediated angiogenesis, and tumor angiogenesis. In these studies, microvascular flow is measured in order to assess the total impact of adaptations at different vascular levels. High-resolution methods for imaging larger vessels have been developed in order to derive "angiograms" of arteries, veins, and medium to large microvessels. We describe a novel method of vascular bed (microvessel and arterial) characterization of vessel anatomy and flow simultaneously, using serial measurement of the fractal dimension (FD) of a temporal sequence of CEU images. This method is proposed as an experimental methodology to distinguish ischemie from nonischemic tissue. Moreover, an improved approach for extracting the FD unique to this application is introduced.

    Original languageEnglish (US)
    Article number1661702
    Pages (from-to)1079-1086
    Number of pages8
    JournalIEEE Transactions on Medical Imaging
    Issue number8
    StatePublished - Aug 1 2006



    • Contrast enhanced ultrasound (CEU)
    • Fractal dimension (FD)
    • Ischemia

    ASJC Scopus subject areas

    • Software
    • Radiological and Ultrasound Technology
    • Computer Science Applications
    • Electrical and Electronic Engineering

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