ANALYTICAL MODEL to ESTIMATE EQUIVALENT DOSE from INTERNAL NEUTRONS in PROTON THERAPY of CHILDREN with INTRACRANIAL TUMORS

Kyle J. Gallagher, Phillip J. Taddei

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

This study developed a computationally efficient and easy-to-implement analytical model to estimate the equivalent dose from secondary neutrons originating in the bodies ('internal neutrons') of children receiving intracranial proton radiotherapy. A two-term double-Gaussian mathematical model was fit to previously published internal neutron equivalent dose per therapeutic absorbed dose versus distance from the field edge calculated using Monte Carlo simulations. The model was trained using three intracranial proton fields of a 9-year-old girl. The resulting model was tested against two intracranial fields of a 10-year-old boy by comparing the mean doses in organs at risk of a radiogenic cancer estimated by the model versus those previously calculated by Monte Carlo. On average, the model reproduced the internal neutron organ doses in the 10-year-old boy within 13.5% of the Monte Carlo at 3-10 cm from the field edge and within a factor of 2 of the Monte Carlo at 10-20 cm from the field edge. Beyond 20 cm, the model poorly estimated H/DRx, however, the values were very small, at <0.03 mSv Gy-1

Original languageEnglish (US)
Pages (from-to)460-468
Number of pages9
JournalRadiation Protection Dosimetry
Volume183
Issue number4
DOIs
StatePublished - Jun 1 2019

ASJC Scopus subject areas

  • Radiation
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Public Health, Environmental and Occupational Health

Fingerprint Dive into the research topics of 'ANALYTICAL MODEL to ESTIMATE EQUIVALENT DOSE from INTERNAL NEUTRONS in PROTON THERAPY of CHILDREN with INTRACRANIAL TUMORS'. Together they form a unique fingerprint.

Cite this