@article{fac8c483440b4c599dea2ff47e56129d,
title = "Analysis of Ugandan cervical carcinomas identifies human papillomavirus clade–specific epigenome and transcriptome landscapes",
abstract = "Cervical cancer is the most common cancer affecting sub-Saharan African women and is prevalent among HIV-positive (HIV+) individuals. No comprehensive profiling of cancer genomes, transcriptomes or epigenomes has been performed in this population thus far. We characterized 118 tumors from Ugandan patients, of whom 72 were HIV+, and performed extended mutation analysis on an additional 89 tumors. We detected human papillomavirus (HPV)-clade-specific differences in tumor DNA methylation, promoter- and enhancer-associated histone marks, gene expression and pathway dysregulation. Changes in histone modification at HPV integration events were correlated with upregulation of nearby genes and endogenous retroviruses.",
author = "Alessia Gagliardi and Porter, {Vanessa L.} and Zusheng Zong and Reanne Bowlby and Emma Titmuss and Constance Namirembe and Griner, {Nicholas B.} and Hilary Petrello and Jay Bowen and Chan, {Simon K.} and Luka Culibrk and Darragh, {Teresa M.} and Stoler, {Mark H.} and Wright, {Thomas C.} and Patee Gesuwan and Dyer, {Maureen A.} and Yussanne Ma and Mungall, {Karen L.} and Jones, {Steven J.M.} and Carolyn Nakisige and Karen Novik and Jackson Orem and Martin Origa and Gastier-Foster, {Julie M.} and Robert Yarchoan and Corey Casper and Mills, {Gordon B.} and Rader, {Janet S.} and Ojesina, {Akinyemi I.} and Gerhard, {Daniela S.} and Mungall, {Andrew J.} and Marra, {Marco A.}",
note = "Publisher Copyright: {\textcopyright} 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.",
year = "2020",
month = aug,
day = "1",
doi = "10.1038/s41588-020-0673-7",
language = "English (US)",
volume = "52",
pages = "800--810",
journal = "Nature genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "8",
}