Analysis of the Effect of Race, Socioeconomic Status, and Center Size on Unrelated National Marrow Donor Program Donor Outcomes: Donor Toxicities Are More Common at Low-Volume Bone Marrow Collection Centers

Bronwen E. Shaw, Brent R. Logan, Deidre M. Kiefer, Pintip Chitphakdithai, Tanya L. Pedersen, Hisham Abdel-Azim, Muneer H. Abidi, Gorgun Akpek, Miguel A. Diaz, Andrew S. Artz, Christopher Dandoy, James L. Gajewski, Peiman Hematti, Rammurti T. Kamble, Kimberley A. Kasow, Hillard M. Lazarus, Jane L. Liesveld, Navneet S. Majhail, Paul V. O'Donnell, Richard F. OlssonBipin N. Savani, Raquel M. Schears, David F. Stroncek, Galen E. Switzer, Eric P. Williams, John R. Wingard, Baldeep M. Wirk, Dennis L. Confer, Michael A. Pulsipher

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    Previous studies have shown that risks of collection-related pain and symptoms are associated with sex, body mass index, and age in unrelated donors undergoing collection at National Marrow Donor Program centers. We hypothesized that other important factors (race, socioeconomic status [SES], and number of procedures at the collection center) might affect symptoms in donors. We assessed outcomes in 2726 bone marrow (BM) and 6768 peripheral blood stem cell (PBSC) donors collected between 2004 and 2009. Pain/symptoms are reported as maximum levels over mobilization and collection (PBSC) or within 2 days of collection (BM) and at 1 week after collection. For PBSC donors, race and center volumes were not associated with differences in pain/symptoms at any time. PBSC donors with high SES levels reported higher maximum symptom levels 1 week after donation (P = .017). For BM donors, black males reported significantly higher levels of pain (OR, 1.90; CI, 1.14 to 3.19; P = .015). No differences were noted by SES group. BM donors from low-volume centers reported more toxicity (OR, 2.09; CI, 1.26 to 3.46; P = .006). In conclusion, race and SES have a minimal effect on donation-associated symptoms. However, donors from centers performing ≤ 1 BM collection every 2 months have more symptoms after BM donation. Approaches should be developed by registries and low-volume centers to address this issue.

    Original languageEnglish (US)
    Pages (from-to)1830-1838
    Number of pages9
    JournalBiology of Blood and Marrow Transplantation
    Volume21
    Issue number10
    DOIs
    StatePublished - Oct 1 2015

    Fingerprint

    Social Class
    Bone Marrow
    Tissue Donors
    Pain
    Unrelated Donors
    Registries
    Body Mass Index
    Peripheral Blood Stem Cells

    Keywords

    • Bone marrow
    • Donor center
    • Donor toxicities
    • PBSC
    • Race
    • Socioeconomic status
    • Unrelated donor

    ASJC Scopus subject areas

    • Transplantation
    • Hematology

    Cite this

    Analysis of the Effect of Race, Socioeconomic Status, and Center Size on Unrelated National Marrow Donor Program Donor Outcomes : Donor Toxicities Are More Common at Low-Volume Bone Marrow Collection Centers. / Shaw, Bronwen E.; Logan, Brent R.; Kiefer, Deidre M.; Chitphakdithai, Pintip; Pedersen, Tanya L.; Abdel-Azim, Hisham; Abidi, Muneer H.; Akpek, Gorgun; Diaz, Miguel A.; Artz, Andrew S.; Dandoy, Christopher; Gajewski, James L.; Hematti, Peiman; Kamble, Rammurti T.; Kasow, Kimberley A.; Lazarus, Hillard M.; Liesveld, Jane L.; Majhail, Navneet S.; O'Donnell, Paul V.; Olsson, Richard F.; Savani, Bipin N.; Schears, Raquel M.; Stroncek, David F.; Switzer, Galen E.; Williams, Eric P.; Wingard, John R.; Wirk, Baldeep M.; Confer, Dennis L.; Pulsipher, Michael A.

    In: Biology of Blood and Marrow Transplantation, Vol. 21, No. 10, 01.10.2015, p. 1830-1838.

    Research output: Contribution to journalArticle

    Shaw, BE, Logan, BR, Kiefer, DM, Chitphakdithai, P, Pedersen, TL, Abdel-Azim, H, Abidi, MH, Akpek, G, Diaz, MA, Artz, AS, Dandoy, C, Gajewski, JL, Hematti, P, Kamble, RT, Kasow, KA, Lazarus, HM, Liesveld, JL, Majhail, NS, O'Donnell, PV, Olsson, RF, Savani, BN, Schears, RM, Stroncek, DF, Switzer, GE, Williams, EP, Wingard, JR, Wirk, BM, Confer, DL & Pulsipher, MA 2015, 'Analysis of the Effect of Race, Socioeconomic Status, and Center Size on Unrelated National Marrow Donor Program Donor Outcomes: Donor Toxicities Are More Common at Low-Volume Bone Marrow Collection Centers', Biology of Blood and Marrow Transplantation, vol. 21, no. 10, pp. 1830-1838. https://doi.org/10.1016/j.bbmt.2015.06.013
    Shaw, Bronwen E. ; Logan, Brent R. ; Kiefer, Deidre M. ; Chitphakdithai, Pintip ; Pedersen, Tanya L. ; Abdel-Azim, Hisham ; Abidi, Muneer H. ; Akpek, Gorgun ; Diaz, Miguel A. ; Artz, Andrew S. ; Dandoy, Christopher ; Gajewski, James L. ; Hematti, Peiman ; Kamble, Rammurti T. ; Kasow, Kimberley A. ; Lazarus, Hillard M. ; Liesveld, Jane L. ; Majhail, Navneet S. ; O'Donnell, Paul V. ; Olsson, Richard F. ; Savani, Bipin N. ; Schears, Raquel M. ; Stroncek, David F. ; Switzer, Galen E. ; Williams, Eric P. ; Wingard, John R. ; Wirk, Baldeep M. ; Confer, Dennis L. ; Pulsipher, Michael A. / Analysis of the Effect of Race, Socioeconomic Status, and Center Size on Unrelated National Marrow Donor Program Donor Outcomes : Donor Toxicities Are More Common at Low-Volume Bone Marrow Collection Centers. In: Biology of Blood and Marrow Transplantation. 2015 ; Vol. 21, No. 10. pp. 1830-1838.
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    abstract = "Previous studies have shown that risks of collection-related pain and symptoms are associated with sex, body mass index, and age in unrelated donors undergoing collection at National Marrow Donor Program centers. We hypothesized that other important factors (race, socioeconomic status [SES], and number of procedures at the collection center) might affect symptoms in donors. We assessed outcomes in 2726 bone marrow (BM) and 6768 peripheral blood stem cell (PBSC) donors collected between 2004 and 2009. Pain/symptoms are reported as maximum levels over mobilization and collection (PBSC) or within 2 days of collection (BM) and at 1 week after collection. For PBSC donors, race and center volumes were not associated with differences in pain/symptoms at any time. PBSC donors with high SES levels reported higher maximum symptom levels 1 week after donation (P = .017). For BM donors, black males reported significantly higher levels of pain (OR, 1.90; CI, 1.14 to 3.19; P = .015). No differences were noted by SES group. BM donors from low-volume centers reported more toxicity (OR, 2.09; CI, 1.26 to 3.46; P = .006). In conclusion, race and SES have a minimal effect on donation-associated symptoms. However, donors from centers performing ≤ 1 BM collection every 2 months have more symptoms after BM donation. Approaches should be developed by registries and low-volume centers to address this issue.",
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    T2 - Donor Toxicities Are More Common at Low-Volume Bone Marrow Collection Centers

    AU - Shaw, Bronwen E.

    AU - Logan, Brent R.

    AU - Kiefer, Deidre M.

    AU - Chitphakdithai, Pintip

    AU - Pedersen, Tanya L.

    AU - Abdel-Azim, Hisham

    AU - Abidi, Muneer H.

    AU - Akpek, Gorgun

    AU - Diaz, Miguel A.

    AU - Artz, Andrew S.

    AU - Dandoy, Christopher

    AU - Gajewski, James L.

    AU - Hematti, Peiman

    AU - Kamble, Rammurti T.

    AU - Kasow, Kimberley A.

    AU - Lazarus, Hillard M.

    AU - Liesveld, Jane L.

    AU - Majhail, Navneet S.

    AU - O'Donnell, Paul V.

    AU - Olsson, Richard F.

    AU - Savani, Bipin N.

    AU - Schears, Raquel M.

    AU - Stroncek, David F.

    AU - Switzer, Galen E.

    AU - Williams, Eric P.

    AU - Wingard, John R.

    AU - Wirk, Baldeep M.

    AU - Confer, Dennis L.

    AU - Pulsipher, Michael A.

    PY - 2015/10/1

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    N2 - Previous studies have shown that risks of collection-related pain and symptoms are associated with sex, body mass index, and age in unrelated donors undergoing collection at National Marrow Donor Program centers. We hypothesized that other important factors (race, socioeconomic status [SES], and number of procedures at the collection center) might affect symptoms in donors. We assessed outcomes in 2726 bone marrow (BM) and 6768 peripheral blood stem cell (PBSC) donors collected between 2004 and 2009. Pain/symptoms are reported as maximum levels over mobilization and collection (PBSC) or within 2 days of collection (BM) and at 1 week after collection. For PBSC donors, race and center volumes were not associated with differences in pain/symptoms at any time. PBSC donors with high SES levels reported higher maximum symptom levels 1 week after donation (P = .017). For BM donors, black males reported significantly higher levels of pain (OR, 1.90; CI, 1.14 to 3.19; P = .015). No differences were noted by SES group. BM donors from low-volume centers reported more toxicity (OR, 2.09; CI, 1.26 to 3.46; P = .006). In conclusion, race and SES have a minimal effect on donation-associated symptoms. However, donors from centers performing ≤ 1 BM collection every 2 months have more symptoms after BM donation. Approaches should be developed by registries and low-volume centers to address this issue.

    AB - Previous studies have shown that risks of collection-related pain and symptoms are associated with sex, body mass index, and age in unrelated donors undergoing collection at National Marrow Donor Program centers. We hypothesized that other important factors (race, socioeconomic status [SES], and number of procedures at the collection center) might affect symptoms in donors. We assessed outcomes in 2726 bone marrow (BM) and 6768 peripheral blood stem cell (PBSC) donors collected between 2004 and 2009. Pain/symptoms are reported as maximum levels over mobilization and collection (PBSC) or within 2 days of collection (BM) and at 1 week after collection. For PBSC donors, race and center volumes were not associated with differences in pain/symptoms at any time. PBSC donors with high SES levels reported higher maximum symptom levels 1 week after donation (P = .017). For BM donors, black males reported significantly higher levels of pain (OR, 1.90; CI, 1.14 to 3.19; P = .015). No differences were noted by SES group. BM donors from low-volume centers reported more toxicity (OR, 2.09; CI, 1.26 to 3.46; P = .006). In conclusion, race and SES have a minimal effect on donation-associated symptoms. However, donors from centers performing ≤ 1 BM collection every 2 months have more symptoms after BM donation. Approaches should be developed by registries and low-volume centers to address this issue.

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    KW - Donor toxicities

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    KW - Race

    KW - Socioeconomic status

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