Analysis of the conformational behavior and stability of the SAP and TSAP isomers of lanthanide(III) NB-DOTA-type chelates

Gyula Tircso, Benjamin C. Webber, Benjamin E. Kucera, Victor G. Young, Mark Woods

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Controlling the water exchange kinetics of macrocyclic Gd 3+ chelates, a key parameter in the design of improved magnetic resonance imaging (MRI) contrast media, may be facilitated by selecting the coordination geometry of the chelate. The water exchange kinetics of the mono- capped twisted square antiprism (TSAP) being much closer to optimal than those of the mono capped square antiprism (SAP) render the TSAP isomer more desirable for high relaxivity applications. Two systems have been developed that allow for selection of the TSAP coordination geometry in 1,4,7,10-tetraazacyclododecane-1,4,7,10- tetraacetic acid (DOTA)-type Gd 3+ chelates, both based upon the macrocycle nitrobenzyl cyclen. In this paper we report investigations into the stability and formation of these chelates. Particular focus is given to the production of two regioisomeric chelates during the chelation reaction. These regioisomers are distinguished by having the nitrobenzyl substituent either on a corner or on the side of the macrocyclic ring. The origin of these two regioisomers appears to stem from a conformation of the ligand in solution in which it is hypothesized that pendant arms lie both above and below the plane of the macrocycle. The conformational changes that then result during the formation of the intermediate H 2GdL + chelate give rise to differing positions of the nitrobenzyl substituent depending upon from which face of the macrocycle the Ln 3+ approaches the ligand.

Original languageEnglish (US)
Pages (from-to)7966-7979
Number of pages14
JournalInorganic Chemistry
Volume50
Issue number17
DOIs
StatePublished - Sep 5 2011

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry

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